Documents

DB30 - Pituitary Pharmacology

Categories
Published
of 2
All materials on our website are shared by users. If you have any questions about copyright issues, please report us to resolve them. We are always happy to assist you.
Share
Description
fsdf
Transcript
  Pituitary Pharmacology The anterior pituitary produces GH, TSH, ACTH, Prolactin, and FSH/LH.The posterior pituitary stores and releases ADH and oxytocin, both produced in the hypothalaus. Reducing GH secretion GH production is stiulated by GH!H and inhibited by somatostatin . le#ated GH causes acroe$aly.GH stiulates peripheral production o%  IGF-1, which is used to guage GH levels .GH!H is used dia$nostically to deterine GH reser#es in the anterior pituitary.All GH anta$onists except Pegvisomant   act centrally to bloc& GH secretion.''Soatostatin (S!)F* is used to reduce GH secretion by GH'producin$ tuors.''+ctreotide (Sandostatin* is a  somatostatin analogue with longer half life . )t noralies )GF'- in0 o% patients. Side e%%ects include  gallstones  and G) syptos.''Caber$oline is a dopaine'li&e a$ent that noralies )GF'- in 120 o% patients.'' Pegvisomant  is a GH antagonist that prevents dimeriation of the GH receptor  . Thus, it acts  peripherally  to bloc& the action o% GH, rather than centrally to bloc& the synthesis o% GH. This noralies )GF'- in 30 o% patients.(!ayond reo#ed ia$e sho4in$ pe$#isoant anta$oniin$ GH'receptor dieriation.* Reducing Prolactin secretion Prolactin secretion is priarily under inhibitory control by dopamine .Prolactinoas express the D1 dopaine receptor, so they are susceptible to inhibition by dopaine.Dopainer$ic a$ents reduce prolactin synthesis/secretion as 4ell as shrin& prolactinoa tuors.''5roocriptine non'selecti#ely binds D- and D1 receptors.''Caber$oline selecti#ely binds D1 receptors, so it has %e4er side e%%ects.''Per$olide non'selecti#ely binds D- and D1 receptors. )t treats Par&inson6s and prolactinoas. Reducing Gonadotropin secretion Gonadotropins contribute to precocious puberty, prostate cancer, and endoetriosis by boostin$ sex horone production. 5loc&in$ $onadotropins causes cheical castration.Gonadotropins include LH and FSH, 4hich are secreted by the pituitary only in response to  pulsatile Gn!H stimulation #ontinuous Gn!H stimulation down-regulates secretion$ ''Leuprolide is a Gn!H analo$ue that causes cheical castration a%ter a transient rise in $onadotropin le#els. ADH pharmacology and the treatment of diabetes insipidus ''L'ar$inine #asopressin is 7ust noral ADH. )t has a short hal% li%e.''Desopressin (dDA8P* is an  %&H analogue with much longer half life and greater specificity . )GF'   -  Patients should experience polyuria each tie be%ore ta&in$ their next dose. This ensures that the dDA8P has 4orn o%%, 4hich protects a$ainst overdose . +#erdose o% dDA8P causes dan$erous euvolemic hyponatremia .
We Need Your Support
Thank you for visiting our website and your interest in our free products and services. We are nonprofit website to share and download documents. To the running of this website, we need your help to support us.

Thanks to everyone for your continued support.

No, Thanks