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Bispecific Antibody-directed Antitumor Activity of Human CD4+ Helper/Killer T Cells Induced by Anti-CD3 Monoclonal Antibody plus Interleukin 2

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Freshly isolated human CD4+ T cells can not respond to recombinant interleukin 2 (rIL-2) because of their lack of p75 IL-2 receptor expression. However, we succeeded in inducing a marked proliferation of purified CD4+ T cells by activation with rIL-2
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