Health & Medicine

Call for a transdisciplinary research effort targeting the molecular mediators of schizophrenia risk factors in response to socioeconomic conditions

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February 28, 2014 Research to Action Symposium, hosted by Institute for Sustainable Solutions and Social Determinants of Health Initiative Call for a transdisciplinary research effort targeting the molecular mediators of schizophrenia risk factors in response to socioeconomic conditions Annika Eriksson & Brittany Elmore, OHSU
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  • 1. Call for a transdisciplinary research effort targeting the molecular mediators of schizophrenia risk factors in response to socioeconomic conditions presented by Annika Eriksson Graduate Student, Bioinformatics and Computational Biology Oregon Health & Science University email: erikssoa@ohsu.edu
  • 2. Why schizophrenia? ● Good model for nature-nurture interaction ● Notable specific genetic and structural metrics ● Both positive and negative symptoms overlap with other diseases ● Relatively easy to create animal models of disease phenotypes ● Need to understand for clinical purposes what best course of treatment for individual cases
  • 3. Social disadvantage • Reduced health care access • Poor housing • Inadequate nutrition • Low physical activity • Lack of green spaces • Reduced resources for children • Poor public school system • Exposure to violence • Social exclusion and isolation W.H.O 2003; Lasky-Su, Faraone, Lange, & Tsuang 2007; Krabbendam, Hooker, Aleman
  • 4. Development of a methodology ● Attention to experimental design ● Appropriate data analysis ● Emphasis on reproducibility ● Generalizable enough to apply to the study of other disease states
  • 5. In conclusion In order to assess total influences on schizophrenia, we need to understand better which environmental factors contribute to genetic effects or provide buffers against these changes during early life. How can we model the complex interactive relationship between biomedical characteristics and the experience of social defeat? Thanks to Brittany Elmore, Graduate Student of Public Health at OHSU
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