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The Clearance Mechanism of Chilled Platelets - Hoffmeister et al

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  EndotheliumPlateletsVesselwall Tissue    Factor  Thrombosis Background 1 Platelet Activation Tissue    Factor  Hemostasis Flow Thrombin ADP    TxA2PGI2Tissue    Factor  Rest Flow NOCD39  ActivatingInhibitory  Platelets stop bleeding, but unwarranted activation causes thrombosis  Circulating PlateletsMegakaryocyte Thrombopoiesis Homeostasis Clearance HepatocytesMacrophagesHemostasis/thrombosis   Background  Average platelet lifespan is ~7-10 days in humansand ~4-5 days in mice  MegakaryocyteCirculating Platelets Thrombopoiesis Clearance HepatocytesMacrophagesHemostasis/thrombosis Homeostasis   Background SplenectomyCancerET Pathological states resulting in increased production lead to thrombocythemia  MegakaryocyteCirculating Platelets Thrombopoiesis Clearance HepatocytesMacrophagesHemostasis/thrombosis Homeostasis   Background Decreased production or greater clearanceleads to thrombocytopenia ImmuneTraumaLeukemiaBMF
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