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A.acid Metabolism

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Amino Acid Metabolism Hanley N. Abramson Professor of Pharmaceutical Sciences Wayne State University December 2009 Dynamics of Protein And Amino Acid Metabolism Dietary Proteins Digestion to Amino Acids Transport in Blood to Cells Protein Synthesis Functional Proteins Amino Acids Protein Degradation In Proteasomes Following Tagging With Ubiquitin 2 Metabolites Digestion of Proteins Stomach: Pepsinogen Pepsin (max. act. pH 2) Enteropeptidase Small Intestine: Trypsinogen Trypsin Tryps
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   Amino Acid Metabolism Hanley N. AbramsonProfessor of Pharmaceutical SciencesWayne State University December 2009  2 Dynamics of Protein And Amino Acid Metabolism Dietary Proteins Digestion to Amino AcidsTransport in Blood to CellsProtein Synthesis Functional ProteinsProtein Degradation InProteasomes FollowingTagging With Ubiquitin Amino AcidsMetabolites  3 Digestion of Proteins Stomach: Pepsinogen Pepsin (max. act. pH 2)Small Intestine: Trypsinogen TrypsinTrypsin cleaves:Chymotrypsinogen to chymotrypsinProelastase to elastaseProcarboxypeptidase to carboxypeptidase Aminopeptidases (from intestinal epithelia) Enteropeptidase  4 L umen  Amino Acids Oligopeptides Intestinal Absorption Oligopeptides Amino Acids Peptidases Blood  Transport Protein
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