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A Seminar Report On ZIKA VIRUS In Partial Fulfillment for the Requirement of Degree of Master of Technology In Biotechnology

Zika fever (also known as Zika virus disease) is an illness caused by the Zika virus.( WHO. January 2016. Retrieved 3 February 2016 )Most cases have no symptoms, but when present are usually mild and can resemble dengue fever.(
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  1 A Seminar Report On ZIKA VIRUS Submitted to: APJAK Technical University, Lucknow In Partial Fulfillment for the Requirement of Degree of Master of Technology In Biotechnology By Aarti Gautam (1400454501) Under The Supervision of Er. V.K. Srivastava Post Graduate Department of Biotechnology R.B.S. Engineering Technical Campus, Bichpuri, Agra-283105  2 ACKNOWLEDGEMENTS The present work was carried out in the R.B.S. Engineering Technical Campus, Agra  during the session 2015-2016. We are greatly indebted to The Director, R.B.S. Engineering Technical Campus, Agra, U.P.  for providing the excellent facilities for carrying out this work. The work on this project has been an inspiring, exciting, sometimes challenging, but always interesting experience. It has been made possible by many other people, who have supported us. We owe our warm gratitude to our project supervisor Er. Vivek Kumar Srivastava,   Post Graduate   Department of Biotechnology, R.B.S. Engineering Technical Campus, Agra, U.P . for cooperation, criticism, encouragement, and numerous discussing during our work. We are thankful to Er. V.K. Srivastava, head of Post Graduate Department of Biotechnology, R.B.S. Engineering Technical Campus, Agra, U.P. for immense support and guidance during our work. We are thankful to Er. Ashish Shukla, Er. Anuj Rohtagi, Er. Taruna Mohnani Er.Shirya Srivastava,vishali singh for their support during the project. We are also thankful to the lab staff of our college Mr. Ashalam, Mr. Arjun for their continuous support during the project. We are especially thankful to Er. Vivek Kumar Srivastava for giving an opportunity to do this necessary for us to complete the whole work. We are also great full of our college library. Finally, we wish to thanks our parents and our friends for their continuous support and their encouragement.  3 DECLARATION I, Aarti Gautam student of (BT) hereby declare that the report titled “ ZIKA VIRUS ”  which is submitted by me to the Post Graduate Department of Biotechnology, R.B.S. Engineering Technical Campus, Bichpuri, Agra-283105, in partial fulfillment of the requirement for the award of the degree of M. Tech in Biotechnology has not previously formed the basis for the award of any Degree, Diploma, Associateship, Fellowship or other similar title or recognition. This work of mine is carried out at R.B.S. Engineering technical campus, Bichpuri, Agra-283105 Place & Date: (Signature and Name of the Applicant)  4 TABLE OF CONTENTS I. ACKNOWLEDGEMENT 2 II. DECLARATION 3 1.   INTRODUCTION 5 1.1   Sign & Symptoms 1.1.1   Guillian Bare Syndrome 6 1.1.2   Pregnency 6 1.2   Causes 7 1.3   Transmission 7 1.3.1   Virology & pathogenesis 7 1.3.2   Vector 8 1.4   Diagnosis 9 1.4.1   Screeing in Pregnency 9 1.4.2   Infant Testing 9 1.5   Prevention 10 1.5.1   Vaccine Devlopment 11 1.5.2   CDC Travel Alert 12 1.5.3   WHO Response 12 1.6   Treatment 12 2.0 Epidemeology 13 2.1Virus Isolation in monkey & mosquitoes 13 2.2 First Evidence of human Infection 1952 14 2.3 Spread in equatorial Africa and to Asia, 1951  –  1981 14 2.4 Micronesia 2007 15 2.5 Americas 2015 15 3.0 Methods 16 3.1 Analysis Of Patient Samples 16 3.2 Serological Testing 16 3.3 Real Time PCR 16 4.0 REVIEW OF LITERATURE 16-17 5.0 FUTURE OUTBREAK 18 6.0 CONCLUSION 18-19 7.0 REFERENCES 20-22    5 1.0 INTRODUCTION:- Zika fever (also called Zika virus disease) is associate degree unwellness caused by the Zika virus.( WHO. Gregorian calendar month 2016. Retrieved three Feb 2016) most cases don't have any symptoms, however once gift area unit sometimes delicate and may correspond infectious disease. ( Retrieved twenty two Gregorian calendar months 2015) Symptoms typically last but seven days. (Chen et al., 2016). "Zika Virus: Rapid Spread within the New World. "Symptoms may include fever, red eyes,  joint pain, headache, and a maculopapular rash. it's not caused any reported deaths throughout the initial infection. Infection has been joined to Guillain  –  Barré syndrome (GBS). Zika fever is principally unfold via the bite of mosquitoes of the arthropod genus kind. It can even be probably unfold by sex and blood transfusions. The disease may spread from mother-to-child within the womb and cause microcephaly. Diagnosis is by testing the blood, urine, or saliva for the virus's RNA when the person is sick. interference involves decreasing mosquitoes bites in areas wherever the illness happens. Efforts embody the utilization of repellent, covering abundant of the body with consumer goods, dipteran nets, and obtaining eliminate standing water wherever mosquitoes reproduce. there's no effective immunizing agent. Health officers counseled that ladies in areas plagued by outbreaks think about laying aside physiological condition thanks to the 2015  –  16 Zika outbreaks which pregnant lady not travel areas wherever outbreaks were occurring. Whereas there's no specific treatment, paracetamol (acetaminophen) could facilitate with the symptoms. Admission to hospital is never necessary. The virus that causes the disease was first isolated in 1947.The first documented outbreak among people occurred in 2007 in the Federated States of Micronesia. As of January 2016, the disease was occurring in twenty regions of the Americas. It is also known to occur in Africa, Asia, and the Pacific. Due to an outbreak which started in Brazil in 2015, the World Health Organization declared it a Public Health Emergency of International Concern in February 2016. 1.1Signs and symptoms:-  The most common signs and symptoms of Zika fever are fever, rash, conjunctivitis (red eyes), muscle and  joint pain, and headache, which are similar to signs and symptoms of dengue and chikungunya fever. The time from a mosquito bite to developing symptoms is not yet known, but is probably a few days to a week. The disease lasts for several days to a week and is usually mild enough that people do not have to go to a hospital.( Vijay 11 feb 2016)  Bleeding has been documented in only one case, with blood seen in semen (hematospermia)( Travassos da Rosa et al., may 2011)  
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