Documents

El-tahihir .A.G.doc

Description
UNIVERSITY OF GEZIRA Deanship of Graduate Studies And Scientific Research Department of Biochemistry & nutrition Micronutrients Profiles of Sudanese patient with kala-azar Gedarif east Sudan Hayat Ahmed Elmahi (B.Sc., M.Sc.) :Supervisor Professor Khalid El-tom Ali :Co-supervisors Professor El-Tahir Awad Gasim Khalil Professor Osman Khalaf Alla Saeed Associate Professor Ahmed Mudawi Musa A thesis submitted for the fulfillment of PhD degree in Nutritional Biochemistry, University of Gazira Dedica
Categories
Published
of 81
All materials on our website are shared by users. If you have any questions about copyright issues, please report us to resolve them. We are always happy to assist you.
Related Documents
Share
Transcript
  UNIVERSITY OF GEZIRADeanship of Graduate StudiesAnd Scientific ResearchDepartment of iochemistr! nutrition#icronutrients $rofi%es of Sudanese patient &ith 'a%a(a)ar Gedarif eastSudan*a!at Ahmed E%mahi +,Sc,- #,Sc,.Super/isor 0$rofessor 1ha%id E%(tom A%i2o(super/isors0 $rofessor E%(Tahir A&ad Gasim 1ha%i%$rofessor Osman 1ha%af A%%a Saeed Associate $rofessor Ahmed #uda&i #usaA thesis su3mitted for the fu%fi%%ment of $hD de4ree in Nutritiona%iochemistr!- Uni/ersit! of Ga)ira  Dedication I dedicate this &or' to m! %o/in4 #other as an! success andachie/ements I accomp%ish are the resu%t of her 'ind %o/e and carin4heart- to sou% of m! Father &ho made sure that a%% his chi%dren are &e%%educated and am3itious- to m! hus3and for his end%ess support and patience to m! t&o dau4hters for their support- %o/e and assistance- tom! a%% fami%! and friends for their support and encoura4ement toaccomp%ish this &or' , 5  Specia% dedication to the peop%e sufferin4 of 1a%a(A)ar and for e/er!mother and father &ho %ost a chi%d- for that &e shou%d ha/e done more totreat this dead%! disease,A3stract0 Background: Zinc -copper Iron are essentia% for norma% human de/e%opment andfunctionin4 of the 3od!, The! ha/e 3een imp%icated to p%a! importantro%es in immune(ph!sio%o4ic functions, 6*O +5778. ,There are /er!fe& studies that ha/e addressed 3et&een V,9 and micronutrient statusinteractionsViscera% %eishmaniasis +V9. is a fata% form of 9, dono/ani infections thataffects interna% or4ans, The disease is an important cause of mor3idit!and morta%it! that is fata% if not treated, Nutritiona% factors are c%aimed tocontri3ute 4reat%! to V9 suscepti3i%it! and mor3idit!:morta%it!, #icro(nutrients deficiencies ha/e 3een associated &ith a num3er of diseases, Aims: This stud! is underta'en to e;p%ore the %e/e% of )inc- copper Iron as&e%% as )inc:copper ratio amon4 V,9 patients <  Materials & Methods: This case(contro% stud! &as carried out in eastern Sudan in Gedarif state- Eastern Sudan an area that is endemic for V9 +1a%a(a)ar.Fo%%o&in4 informed consent- <=< &ith parasito%o4ica%%! confirmed V9and 57> apparent%! hea%th comparators &ere enro%%ed, Recruitment &ascarried out at 1assa3 Rura% *ospita%- &here %!mph nodes and 3onemarro& aspirates are the routine methods for V9 dia4nosis,The stud! continued for three !ears +No/em3er <>>8 ?#arch <>>@.,Demo4raphic and c%inica% data- nutrition assessment and anthropometricmeasurements &ere co%%ected in a specia%%! desi4ned report forms,Venous 3%ood &as co%%ected and serum &as separated for 3iochemistr!-haemato%o4! and Iron- Zinc 2opper estimation, , $re4nant &omen-*IV I:II reacti/e- patients &ith acti/e pu%monar! T3 &ere e;c%uded , Results and discussion: The means a4e of V9 patients and the comparator &ere 5,8>B55,C>!ears and C,5 B5,= !ears respecti/e%!, The ma%e fema%e ratio in patients &as C0< compared to 50< in hea%th! contro%s, The mains!mptoms and si4ns are fe/er- &astin4 and anaemia &ith a meanduration of i%%ness of ,C<BC,5 &ee's The #I is si4nificant%! %o& in patients +5<,< B 8,5. compared &ith hea%th! contro%s +57,@BC,8. p /a%ue>,>>5, *3 is compara3%e @,5B5,7- 55,= B<,> +p /a%ue >,5.,The tota% serum protein and serum a%3umin in patients +8,= B5,C C,<B@.-are si4nificant%! %o&er compared to hea%th! contro%s +,< B>,@ C, B>,.+p /a%ues0 >,>< and >,>7 respecti/e%!.,Serum iron %e/e%s in patients and contro%s +=>,BC7,@- @>,=B<,8. andSerum Zin' %e/e%s +8, @B<@,- @7,8,=BCC. are %o&er in patientscompared to hea%th! contro%s +p /a%ue >,>>5., Serum 2opper %e/e%s in patients and contro%s are compara3%e +@,<BC,5- 8@,= B,<respecti/e%!. p /a%ue >,,2orre%ation 3et&een Zinc- copper- iron &ith disease duration Summary C  Serum iron &as found si4nificant%! %o&er in V9 patients compared tocomparators- there &as si4nificant corre%ation of %o& iron %e/e%s anddisease duration, The Zinc %e/e% &as si4nificant%! %o&er in patientscompared to comparators, There &as si4nificant corre%ation of %o& Zinc%e/e%s and disease duration, On the other hand 2opper is si4nificant%!hi4her in patients compared to comparators, There &as si4nificantcorre%ation of hi4h 2opper %e/e%s and disease duration, Conclusion and recommendations  Nutritiona% and micronutrient status ha/e %on4 3een 'no&n to inf%uencethe ris' of infectious diseases A%thou4h it is 'no&n that nutritiona% statusmi4ht inf%uence the outcome of different infections- , a%ancedmicronutrients supp%ementation durin4 V9 ma! positi/e%! impact theoutcome of the disease,1e!&ords Zinc- 2opper Iron Anemia- ma%nutrition- V,9 Gedarif -Sudan 
Search
Tags
Related Search
We Need Your Support
Thank you for visiting our website and your interest in our free products and services. We are nonprofit website to share and download documents. To the running of this website, we need your help to support us.

Thanks to everyone for your continued support.

No, Thanks