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General Pathophysiology of Leptospirosis 1 (Autorecovered)

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   Manuel S. Enverga University Foundation Lucena City Granted Autonomous Status CHED CEB Res.076-2009 COLLEGE OF NURSING & ALLIED HEALTH SCIENCES   GENERAL PATHOPHYSIOLOGY OF LEPTOSPIROSIS BOOK BASED) MODIFIABLE FACTORS ETIOLOGIC AGENTS NON-MODIFIABLE FACTORS Occupational exposure: Leptospira (L. interrogans) Age -Farmers L. icterohaemorrhagiae Sex -Veterinarians L. bataviae Geographic -Rice field workers L. canicola Season -Butchers L. grippotyphosa Recreational activities: -Fresh water swimming -Canoeing -Kayaking -Trail biking in warm areas Household exposure: -Pet dogs -domestic livestock -Infected rodents Leptospira lives in the kidneys of animals Portal exit through urine Contaminates the water and soil   Manuel S. Enverga University Foundation Lucena City Granted Autonomous Status CHED CEB Res.076-2009 COLLEGE OF NURSING & ALLIED HEALTH SCIENCES  Bacteria enters through break in the skin, mouth, and eyes Incubates for 6-15 days Proliferation and widespread SEPTIC STAGE Bacteria enters the bloodstream S/sx:  - chills, fever, increase RR and HR, abdominal pain, headache, Attach to endothelial cells Induced endotoxins asymptomatic 4-7 days Phagocytosis Release of IgG antibodies Adequate immune response, bacteria cleared Inadequate immune response, hemolysis, lipolysis   Manuel S. Enverga University Foundation Lucena City Granted Autonomous Status CHED CEB Res.076-2009 COLLEGE OF NURSING & ALLIED HEALTH SCIENCES  Capillary vasculitis Endothelial edema and lymphatic inflammation, Hypovolemia s/sx : low BP, increase HR, weak pulse, shallow breathing, profuse breathing, and decrease urine output Leakage s/sx: petchiae, intraparenchymal bleeding, bleeding long serosa and mucosa Bacteria proliferates in the blood Distributed around the body via lymphatic involvement s/sx: lymphadenopathy, fever, chills, malaise, loss of appetite, headache. IMMUNE/TOXIC STAGE 4-30 Days Organ system affectation CONVALESCENCE STAGE Relapse occur during 4 th -5 th  week   Manuel S. Enverga University Foundation Lucena City Granted Autonomous Status CHED CEB Res.076-2009 COLLEGE OF NURSING & ALLIED HEALTH SCIENCES  KIDNEYS Accumulation of bacteria in the lobes RENAL FAILURE Accumulation of bacteria in the renal tubules and tubular lumen Increase BUN and serum creatinine LIVER Centribular necrosis and kupffer cell proliferation Development of interstitial and tubular necrosis Vascular damage Hypervolemia Decrease renal blood flow Decrease glomerular filtration Further loss of nephron function Decrease renal function   Hepatocellular dysfunction Hepatocellular  jaundice s/sx: yellow tinted skin and eyes, inflammation of the liver Hepatocellular dysfunction DIC Hypovolemia

Gypsy Jazz

Sep 22, 2019
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