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Plasma cell dyscraises by asif ppt

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Plasma cell dyscraises By Asif Zeb Sir Hematologist
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  Plasma cell dyscrasias Muhammad Asif ZebLecturer HematologyIPMS-KMU  Plasma cell neoplasms  Plasma cell neoplasms are a diverse group of B cells disorders in which monoclonal immunoglobulins are secreted in the serum or urine  Plasma cell disorders  Monoclonal gammopathy of undetermined significance (MGUS)  Plasmacytoma  Multiple myeloma  Waldenstroms macroglobinemia  Light chain disease  Heavy chain disease  Key features of plasma cell neoplasms neoplasmsfeaturesMultiple myelomaLytic bone lesions “M” spike on serum/ urine electrophoresis Rouleaux on blood smear >20% plasma cells in bone marrow plasmacytomaLocalized mass Monoclonal plasma cellsMonoclonal gammopathy of undetermined significance Monoclonal serum proteinBence jones protein absent Bone marrow plasma cells <10% Waldenstroms macroglobulinemiaHyperviscositysyndrome   gMmonoclonal protein  Multiple myeloma  Multiple myeloma is a neoplastic proliferation of bone marrow plasma cells characterized by lytic bone lesions, presence of monoclonal proteins in serum (paraproteinaemia) and urine  or   Multiple myeloma is a B-cell malignancy characterized by a monoclonal expansion and accumulation of abnormal plasma cells in the bone marrow compartment. 
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