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Association between markers of endothelial dysfunction and early signs of renal dysfunction in pediatric obesity and type 1 diabetes M. Loredana Marcovecchio, Tommaso de Giorgis, Simone Franchini, Daniela Caniglia, Francesco Chiarelli, Angelika Mohn Department of Paediatrics, University of Chieti, Chieti, Italy Presenter Disclosure Information M. Loredana Marcovecchio Disclosed no conflict of interest. Background Obesity and type 1 diabetes (T1D) are two dysmetabolic conditions that are inc
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  Association between markers of endothelial dysfunction and early signs of renal dysfunction in pediatric obesity and type 1 diabetes   M. Loredana Marcovecchio, Tommaso de Giorgis, Simone Franchini, Daniela Caniglia, Francesco Chiarelli, Angelika Mohn Department of Paediatrics, University of Chieti, Chieti, Italy  Presenter Disclosure Information M. Loredana Marcovecchio   Disclosed no conflict of interest.  Background Obesity and type 1 diabetes (T1D) are two dysmetabolic conditions that are increasing in prevalence among children and adolescents. Ogden CL et al., JAMA 2014; Patterson CC et al., Lancet 2009 Both conditions are recognized to be associated with an increased risk of developing cardiovascular disease and microvascular complications. Shay CM et al., Circulation 2013; Franchini S et al., Pediatr Diabetes 2014   Common mechanisms implicated in vascular disease in obesity and T1D are inflammation and oxidative stress, which both contribute to endothelial dysfunction. Ceriello A et al., Arterioscler Thromb Vasc Biol 2004  Background Increased levels of inflammatory and oxidative stress markers, such intercellular adhesion molecule-1 (ICAM-1) and myeloperoxidase (MPO), have been associated with the development of endothelial dysfunction. Szimiko PE et al., Circulation 2003; Lau D et al., Pharmacol Ther 2006 Data on the potential role of these markers in the pathogenesis of obesity- and diabetes-related vascular disease in the pediatric population are limited, and they have not been compared between youth with obesity and those with T1D.

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Jul 23, 2017
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