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ACCUMULATION OF SKIN ADVANCED GLYCATION END-PRODUCTS ARE ASSOCIATED WITH EARLY RETINOPATHY IN YOUTH WITH TYPE 1 DIABETES Yoon Hi Cho1,2, Maria E Craig1,2,3, Andrzej Januszewski4, Stephen Hing1, Alicia Jenkins4, Kim C Donaghue1,2 1. Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead 2. Discipline of Paediatrics and Child Health, The University of Sydney 3. School of Women's and Children's Health, University of New South Wales 4. NHMRC Clinical Trials Centre, The Universi
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  ACCUMULATION OF SKIN ADVANCED GLYCATION END-PRODUCTS ARE ASSOCIATED WITH EARLY RETINOPATHY IN YOUTH WITH TYPE 1 DIABETES   Yoon Hi Cho 1,2 , Maria E Craig 1,2,3 , Andrzej Januszewski 4 , Stephen Hing 1 , Alicia Jenkins 4 , Kim C Donaghue 1,2 1. Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead 2. Discipline of Paediatrics and Child Health, The University of Sydney 3. School of Women's and Children's Health, University of New South Wales 4. NHMRC Clinical Trials Centre, The University of Sydney  BACKGROUND Advanced glycation end products ã Advanced glycation end-products (AGEs) are proteins or lipids glycated after exposure to sugars ã AGEs accumulate with age, age-related diseases such as atherosclerosis and Alzheimer’s disease, chronic renal failure ã AGE accumulation also accelerated in diabetes; enhanced by elevated glucose and oxidative stress and so implicated in pathogenesis of diabetes complications  ã AGE measurement: plasma and skin biopsies ã Non-invasive measure of skin autofluorescence (AF) - correlates well with skin biopsy quantification ã AGEs can be fluorescent (e.g. pentosidine) and non-fluorescent AGE (e.g. Nε -(carboxymethyl)lysine [CML]). ã Fluorescent AGEs: a characteristic fluorescence spectrum at 440 nm. ã Skin AF associated with microvascular complications in adults with type 1 and 2 diabetes. No data in adolescents. AGEs  AIMS 1. To compare AGE accumulation, as measured by skin autofluorescence (AF), in young people with type 1 diabetes (T1D) vs controls 2. To examine putative association between skin autofluorescence (AF) and diabetic retinopathy

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Jul 23, 2017
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