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Predictors for vascular disease hospitalisations in young adults with childhood onset T1DM; insights from 20 years of follow up MN Cooper1-2, MI de Bock2, TW Jones1-3, EA Davis1-3 1 Telethon Kids Institute, The University of Western Australia, Perth, Australia 2 Department of Endocrinology and Diabetes, Princess Margaret Hospital for Children, Perth, Australia 3 The School of Paediatrics and Child Health, The University of Western Australia, Perth, Australia 2014 ISPAD Conference 3rd September
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  Predictors for vascular disease hospitalisations in young adults with childhood onset T1DM; insights from 20 years of follow up   MN Cooper 1-2 , MI de Bock 2 , TW Jones 1-3 , EA Davis 1-3 1 Telethon Kids Institute, The University of Western Australia, Perth, Australia 2 Department of Endocrinology and Diabetes, Princess Margaret Hospital for Children, Perth, Australia 3 The School of Paediatrics and Child Health, The University of Western Australia, Perth, Australia 2014 ISPAD Conference 3 rd  September  Background Difficulties comparing studies  – Differences in cohort definition / ascertainment  – Differences in follow-up methods  – Differences in endpoint definition Shortage of population based studies with clinical data for analysis of potential risk factors together with a control population  Objectives Calculate the incidence rate of microvascular and macrovascular complications requiring hospitalisation, in a population based T1D cohort, diagnosed in childhood. Compare those incidence rates with that of the (background) general population Examine the association of clinical and demographic risk factors for increased risk of hospitalisation for microvascular and macrovascular complications  Methods - Datasets WACDD  –   Western Australian Children’s Diabetes Database    – WA ~2.4 mil, single tertiary hospital based team, ~3-monthly visits  – Stored electronically with consent since 1987, 99% ascertainment Birth Register and Mortality Register  – 1974 and 1969 onwards respectively  – ICD 9, 9CM, 10AM coded cause of death information Hospital Morbidity Data Collection  – 1970 onwards  – All public and private hospital separations in Western Australia  – ICD 9, 9CM, 10AM coded diagnosis and procedure data
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