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DEPTOR 5'UTR polymorphisms and insulin resistance in obese children and adolescents Jernej Kovač1, Tamara Šutuš1, Simon Horvat2, Jasmina Beltram2, Katarina Trebušak Podkrajšek1, Tadej Battelino3,4, Primož Kotnik3 1. Unit for Special Laboratory Diagnostics, University Children's Hospital, UMC Ljubljana, Ljubljana, Slovenia 2. National Institute of Chemistry, Ljubljana, Slovenia 3. Department of Endocrinology, Diabetes and Metabolic Diseases, University Children's Hospital, UMC Ljubljana, Ljubljan
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  DEPTOR   5'UTR polymorphisms and insulin resistance in obese children and adolescents Jernej Kovač 1 , Tamara Šutuš 1 , Simon Horvat 2 , Jasmina Beltram 2 , Katarina Trebušak Podkrajšek 1 , Tadej Battelino 3,4 , Primož Kotnik 3 1. Unit for Special Laboratory Diagnostics, University Children's Hospital, UMC Ljubljana, Ljubljana, Slovenia 2. National Institute of Chemistry, Ljubljana, Slovenia 3. Department of Endocrinology, Diabetes and Metabolic Diseases, University Children's Hospital, UMC Ljubljana, Ljubljana, Slovenia 4. Department of Paediatrics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia  Presenter Disclosure Information Primož Kotnik   Disclosed no conflict of interest.  Background ã Obese children and adolescents are prone to become overweight or obese adults and will present with obesity complications at that time, however selected will develop them early. ã Impaired sensitivity of tissues to insulin (especially liver, skeletal muscle and adipose tissue) is possibly the main metabolic complication of obesity. ã Goal is to early recognize those at risk of obesity’s complications  and aplly efficient therapeutic strategies to battle obesity and its complications. ã Genetic background has an important role in the development of IR and T2D  –  genetic markers for the determination of increased risk? Reilly 2011, Weiss 2013  mTOR (Mammalian Target of Rapamycin) ã The mTOR signaling pathway senses growth factors and nutrients to regulate many biological processes involved in the promotion of cell growth. ã mTORC1:  – affects lipogenesis and adipogenesis.  – directly involved in insulin   downstream signalling through the feedback control of insulin receptor substrate 1 (IRS-1). ã mTOR signalling deregulation leads to obesity and increased risk of insulin resistance (IR) and type   2 diabetes. Laplante 2012, Cornu 2013 http://www.cellsignal.com/
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