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[3]-Drug Metabolism-Lect.ppt

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Introduction  Drug metabolism (biotransformation or detoxication) is the biochemical changes of the drugs and other foreign substances in the body.  This is leading to the formation of different metabolites with different effects.  Some of the compounds are excreted partially unchanged and some are known to be converted to products, which may be more active or more toxic than the parent compounds.  The liver is the major site of drug metabolism, but specific drugs may undergo biotr
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  Introduction  Drug metabolism (biotransformation or detoxication)  is the biochemical changes of the drugs and other foreign substances in the body.  This is leading to the formation of different metabolites with different effects.  Some of the compounds are excreted partially unchanged and some are known to be converted to products, which may be more active or more toxic than the parent compounds.  The liver is the major site of drug metabolism, but specific drugs may undergo biotransformation in other tissues.    Importance  Drug metabolism is needed to convert non-polar lipophilic compounds (lipid soluble) which the body cannot excrete into more polar hydrophilic compounds (water soluble) which the body can excrete them in short period of time. Because if the lipid soluble non-polar compounds are not metabolized to the polar water soluble compounds, they will remain in the blood and tissues and maintain their pharmacological effects for an indefinite time.    Classification of metabolites:  Inactive metabolites  Metabolites retain similar activity  Metabolites with different activity  Bioactivated metabolites (prodrug technique)

Distance Education

Jul 23, 2017

Case Yankee Hoe

Jul 23, 2017
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