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Gomes MB, Negrato CA, Calliari LE On behalf of the Brazilian Type 1 Study Group (BrazDiab1SG)  Puberty is a life event that may have several relations to later life diseases  Age of menarche is well recalled by adult women and usually a reliable information (Must A. Am J Epidemiol. 2002;155:672–679)  Age of menarche is decreasing all over the world, and also in Brazil (Kac G. Ann Hum Biol 2000; 27 (4):423–428)  Earlier age of menarche has lately been associated to several adverse o
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  Gomes MB, Negrato CA, Calliari LE On behalf of the Brazilian Type 1 Study Group (BrazDiab1SG)   Puberty is a life event that may have several relations to later life diseases  Age of menarche is well recalled by adult women and usually a reliable information (Must A. Am J Epidemiol. 2002;155:672 – 679)  Age of menarche is decreasing all over the world, and also in Brazil (Kac G. Ann Hum Biol 2000; 27 (4):423  – 428)     Earlier age of menarche has lately been associated to several adverse outcomes:  Type 2 diabetes  Obesity  Cardiovascular diseases  Metabolic syndrome   All causes mortality showing that the timing of pubertal development may have lifelong effects on a woman’s health Stockl D.Diabetologia 2012, 55(3):681 – 688. He C. Am J Epidemiol 2010, 171(3):334 – 344. Adair LS. Am J Public Health 2001; 91:642 – 644. Pierce MB. Diabet Med 2012, 29(5):600 – 603   The majority of studies found an association: early pubertal maturation and adverse metabolic outcomes, strong relation with increased adiposity   Stockl D.Diabetologia 2012, 55(3):681 – 688. He C. Am J Epidemiol 2010, 171(3):334 – 344. Adair LS. Am J Public Health 2001; 91:642 – 644. Pierce MB. Diabet Med 2012, 29(5):600 – 603

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