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Renal and retinal complications: lessons from cohort studies Professor Kim Donaghue The Children’s Hospital at Westmead Sydney Children’s Hospitals Network Cohort study design Enrol cohort Follow-up over time with measures of disease and exposure Identify group exposed to study factor Compare disease outcomes Identify group not exposed to study factor At least 80% follow-up rates Analyses are adjusted for all know confounders Follow-up ‘long enough’ No intervention is applied during the
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  Renal and retinal complications:   lessons from cohort studies Professor Kim Donaghue The Children ’ s Hospital at Westmead Sydney Children ’ s Hospitals Network  Enrol cohort Follow-up over time with measures of disease and exposure Identify group exposed to study factor Compare disease outcomes Identify group not exposed to study factor Cohort study design  At least 80% follow-up rates  Analyses are adjusted for all know confounders Follow-up ‘ long enough ’  No intervention is applied during the follow-up period  Cumulative percentage of retinopathy by age at 6yrs duration (NSW 1990-2 Incident Cohort) 0   20   40   60   80   100   5   6   7   8   9   10   11   12   13   14   15   16   17   18   19   20   Age (years)      P  e  r  c  e  n   t  a  g  e   (   %   ) ISPAD GUIDELINES Screening threshold Pediatric Diabetes 2007 8:40-48  Cumulative percentage of borderline AER by age at 6yrs duration (NSW Incident cohort) 0   20   40   60   80   100   5   6   7   8   9   10   11   12   13   14   15   16   17   18   19   20   21   Age (years)      P  e  r  c  e  n   t  a  g  e   (   %   ) ISPAD GUIDELINES Screening threshold Pediatric Diabetes 2007 8:40-48
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