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Bacillus Calmette-Guérin (BCG) vaccination and childhood diabetes in the Québec Birth Cohort on Immunity and Health (QBCIH) M-C Rousseau, M El-Zein, F Conus, L Legault, M-E Parent 40th Annual Conference, ISPAD Toronto, Canada September 5, 2014 Presenter Disclosure Information Marie-Claude Rousseau No conflict of interest to disclose. Background ã Type 1 diabetes: chronic autoimmune process → β-cell destruction ã BCG prevents diabetes in non-obese diabetic (NOD) mice [e.g., Harada, 1990; Qi
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  Bacillus Calmette-Guérin (BCG) vaccination and childhood diabetes in the Québec Birth Cohort on Immunity and Health (QBCIH) 40 th  Annual Conference, ISPAD Toronto, Canada September 5, 2014 M-C Rousseau, M El-Zein, F Conus, L Legault, M-E Parent    Presenter Disclosure Information Marie-Claude Rousseau No conflict of interest to disclose.   Background   ã Type 1 diabetes: chronic autoimmune process → β -cell destruction ã BCG prevents diabetes in non-obese diabetic (NOD) mice [e.g., Harada, 1990; Qin & Singh, 1997; DaRosa, 2013] ãBCG → non -specific immune stimulation (TH1 lymphocytes) Diabetes T H 1 Lymphocytes Stimulation Prevention? BCG IL-1, IL-2, IFN- δ , TNF- α   Potential mechanism   T reg  Effect of BCG on diabetes development in humans ã No association [Blom, 1991; Dahlquist, 1995; Parent, 1997; Wadsworth, 1997; Hummel, 2000] ã Harmful effects −  ↑  autoantibodies (IA-2A) in newborns [Wahlberg, 2003] −  Accelerated progression from autoimmunity to diabetes [Huppmann, 2005]
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