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Anticoagulants, Thrombolytics and Antiplatelet.pptx

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Pharmacological Agents for Coagulation Disorders ã Hemostasis refers to the finely regulated dynamic process of maintaining fluidity of the blood, repairing vascular injury, and limiting blood loss while avoiding vessel occlusion (thrombosis) and inadequate perfusion of vital organs ã Common causes of dysregulated hemostasis: – Hereditary or acquired defects – Secondary effects of infection or CA Mechanism of Blood Coagulation Intrinsic System ã the direct contact of the first clotting fac
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  Pharmacological Agents for Coagulation Disorders  ã Hemostasis refers to the finely regulated dynamic process of maintaining fluidity of the blood, repairing vascular injury, and limiting blood loss while avoiding vessel occlusion (thrombosis) and inadequate perfusion of vital organs ã  Common causes of dysregulated hemostasis: – Hereditary or acquired defects – Secondary effects of infection or CA  Mechanism of Blood Coagulation  Intrinsic System ã the direct contact of the first clotting factor (factor  XII) with the damaged vessel wall activates the clotting factor and initiates the cascade Extrinsic System ã tissue factor (known also as thromboplastin) is released from the damaged vascular cell ã Tissue factor directly activates clotting factor VII,  which then activates subsequent factors in the clotting mechanism

czzz (1)

Jul 23, 2017
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