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Direct effects of doxorubicin on skeletal muscle contribute to fatigue

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Direct effects of doxorubicin on skeletal muscle contribute to fatigue
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  Lecture outline • The nomenclature of Immunology • Types of immunity (innate and adaptive; active and passive; humoral and cell-mediated) • Features of immune responses • The major cells of the immune system  • Basic science: understanding a complex biological system • Impact on many aspects of human disease • Immunization is the ONLY approach for eradicating a disease • New therapies based on biology • Potential for major role in emerging therapies (gene therapy, stem cell therapy) Why the great interest in Immunology?  The functional importance of the immune system  The central questions  • How does the immune system respond to different infections?  – Different types of microbes are eliminated by different effector mechanisms, which are designed to best combat each type of microbe – Antigens are useful models for studying immune responses to microbes  The central questions  • How does the immune system respond to different infections? – Antigens are useful models for studying immune responses to microbes – Different types of microbes are eliminated by different effector mechanisms, which are designed to best combat each type of microbe • Why does the immune system not respond to self antigens?  • What are the pathogenic mechanisms and clinico-pathologic consequences of abnormalities in the immune system? 
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