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Hypoxic Ischemic Encephalopathy

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Hypoxic Ischemic Encephalopathy Prof. Saad S Al-Ani Senior Pediatric Consultant Head of Pediatric Department Khorfakkan Hospital . Sharjah saadsalani@yahoo.com Definitions Anoxia is a term used to indicate the consequences of complete lack of oxygen as a result of a number of primary causes Hypoxia refers to an arterial concentration of oxygen that is less than normal Ischemia refers to blood flow to cells or organs that is insufficient to maintain their normal function Biagioni E, Mercuri
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  Hypoxic Ischemic Encephalopathy Prof. Saad S Al-Ani Senior Pediatric Consultant Head of Pediatric Department Khorfakkan Hospital . Sharjah saadsalani@yahoo.com  05/26/2010 Khorfakkan Hospital Pediatric Department 2   Ischemia    refers to blood flow to cells or organs that is insufficient to maintain their normal function Definitions  Anoxia    is a term used to indicate the consequences of complete lack of oxygen as a result of a number of primary causes Hypoxia    refers to an arterial concentration of oxygen that is less than normal Biagioni E, Mercuri E, Rutherford M, et al: Combined use of electroencephalogram and magnetic resonance imaging in full-term neonates with acute encephalopathy. Pediatrics   2001;107:461    05/26/2010 Khorfakkan Hospital Pediatric Department 3   Hypoxic-ischemic encephalopathy   Is an important cause of permanent damage to CNS cells that may result in neonatal death or be manifested later as cerebral palsy or mental deficiency   Nelson Textbook of Pediatrics 19 th  ed.2010 . pages 566 - 568    05/26/2010 Khorfakkan Hospital Pediatric Department 4   25-30%  of survivors are left with permanent neurodevelopmental abnormalities (cerebral palsy, mental retardation). Dixon G, Badawi N, Kurinczuk JJ, et al: Early developmental outcomes after newborn encephalopathy. Pediatrics   2002;109:26-33 Fifteen to 20%  of infants with hypoxic-ischemic encephalopathy die in the neonatal period  
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