Incretin Based Therapy of Type 2 Diabetes Mellitus_1

diabetes type 2
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  Incretin Based Therapy of Type 2 Diabetes Mellitus BY Prof. ADEL A EL-SAYED MD Prof. of Internal Medicine Sohag Faculty of Medicine SOHAG EGYPT  Pathophysiology of Type 2 Diabetes ã Insulin resistance. ã Beta cell dysfunction.  Pathophysiology of Type 2 Diabetes  Insulin Resistance ã Insulin Resistance starts very early in the course of the disease. ã insulin resistance alone will not produce diabetes. If beta-cell function is normal, one can compensate for insulin resistance by increasing insulin secretion.  Pathophysiology of Type 2 Diabetes  Beta cell defect ã all type 2 patients have at least a relative defect in both beta-cell function and mass. ã Function:  in the (UKPDS), newly diagnosed people with diabetes had, on average, only about 50% of normal beta-cell function .[Diabetes. 1995;44:1249-1258 , Diab Res Clin Pract. 1998;40(suppl):S21-S25.] ã Mass:  Autopsy studies comparing the volume of beta cells in nondiabetic individuals with that of people with diabetes found a 41% decrease in beta-cell mass among people with type 2 diabetes
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