Pathology of the Skin

Kodil skripsi patologi kulit
of 8
All materials on our website are shared by users. If you have any questions about copyright issues, please report us to resolve them. We are always happy to assist you.
Related Documents
  Pathology of the SkinSkin is the only organ system where gross pathology is also the clinical signs of disease. Unfortunately, most skin lesions are not specific for a disease. Nearly all skin lesions are inflammatory (dermatitis).Many skin diseases will possess an array of gross lesions as they progress through stages. Biopsies from multiple areas will result in multiple lesions.istopathology is key and a !iopsy should always !e done. n addition to this you will also use signalment, history, location of lesions, seasonality, presence or a!sence of pruritis and other tests to diagnose. Disease of the Epidermis # most inflammation directed here srcinates in the B$ of the dermis (why we call it dermatitis) Name%haracteristics%ausePredominant Species PUSTULAR DERMATITIS Pustules are aggregates of neutrophils within the epidermis, &isi!le grossly (white to yellow), short li&ed and rupture lea&ing a crust%rust is a sca! resulting from a dried up accumulation of keratin, inflammatory cells, serum and !acteriaSuperficial !acterial infectionPustules in the keratin layerStaphylococcus'olliculitisPustules o&er hair follicles nfection with !acteria, fungi, mitesPemphigus foliaceus%ells separate from each other then detach and float in the  pustule (acanthocytes or acantholytic cells) then turn nti!ody directed against intercellular !ridges of the keratinocytes  into a crust BULLOUS AND VESICULAR DERMATITIS $esicles are fluid filled ca&ities less than *mm in diameter !ull are greater than *mm !oth structures are shortli&ed and turn into crustSpongiosus+dema !etween keratinocytes (intercellular) Intrace!ar edema $esicles form when edema is se&ere enough that keratinocytes are lost or displacedydropic degeneration+dema within the !asal epiderdmal cells causes depigmentation of the skinutoimmune d, lupus erythematosis and dermatomyositis, drug reactionsBallooning degeneration ntracellular edema within superficial keratinocytes$iral skin diseases (po- &irus, foot and mouth, &esicular stomatitis, &esicular e-anthema, swine &esicular disease)Pemphigus &ulgarisSupra!asilar &esicle containing acantholytic cells skin and oral ca&ity! directed against keratinocyteBullous pemphigoidSu!epidermal &esicle skin and oral ca&ity! against the !asement mem!rane NECROTI IN# DERMATITIS  Necrosis of epidermal cells leads to ulceration of the skin macule is a flat discolored area of the skin, papule is slightly raised area !oth are usually red (erythema)  e&entually progress to a crust  phase+rythema multiformeNecrosis of single keratinocytes throughout epidermisd&erse drug reaction in association with systemic infection or neoplasia (immune mediated)Small animalso-ic epidermal necrolysisMore se&ere form, full thickness epidermal necrosisd&erse drug reaction in association with systemic infection or neoplasia (immune mediated)Small animalsBurns+pidermis and dermis are necroticPhotosensitiationNon pigmented areas of skin necrotie ngestion of photodynamic agent in the feed or secondary to chronic li&er disease/arge animals E$UDATIVE AND ULCERATIVE DERMATITIS Produce crusts or secondary ulcers on the skin, may !e se&ere spongiosus of the epidermis, due to edema Aer%ies ntensely pruritic, may !e seasonalypersensiti&ity reaction to antigen that is inhaled or ingested. Most common cause of e-udati&e dermatitis.+osinophils in cats and horses  !ut not dogs.atopyName gi&en to inhalant allergyMost common'ood allergyNot as common+osinophilic granuloma comple- Nodules or papules in the skinalong with ulcers0 histologically different diseases%at and horse, sometimes dogllergic contact dermatitis/esions &ary from papules to crusts and are commonly found on sparsely haired regions (feet, &entral !elly) similar to poison i&y%ontact of skin with an allergic su!stance (chemicals,  plastics)  rritant contact dermatitis/esions in sparsely haired regions, erythematous papulesor ulcers and crusts of e-udati&e dermatitis1irect contact of the skin withirritating o!2ect3 soap, drug, acid, detergentPyotraumatic dermatitis 4hot spots5Se&ere e-udati&e dermatitisSelf inflicted trauma of !iting and scratching due to pain and pruritis of allergic skin disease1og &'PER(ERATOTIC DISEASES yperkeratosis+-cess keratin, flakes or scales (se!orrhea)# orthokeratotic hyperkeratosis(keratinied cells lack a nucleus)Parakeratosis+-cess keratin#parakeratotic hyperkeratosis (nucleus of the cell is retained)6inc or $itamin  deficiencySe!orrhea1ry or oily# rare primary disease# inherited defect of keratin cells# secondary disease is common# after allergy,  parasites, infection, endocrine disease# %ocker spaniel# ll dogs &'PERPLASTIC DERMATITIS %haracteried !y histologic appearance two lesions of chronic skin diseasecanthosisyperplasia of the epidermis, skin thickened grossly with leathery te-ture ( ichenification ), there is also increased melanin pigment making the skin appear darker


Jul 23, 2017


Jul 23, 2017
Related Search
We Need Your Support
Thank you for visiting our website and your interest in our free products and services. We are nonprofit website to share and download documents. To the running of this website, we need your help to support us.

Thanks to everyone for your continued support.

No, Thanks