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1. Beta-blockers 2. Beta-blockers <ul><li>Beta-blockers, such as i , do not enter the brain, but directly r of the s around the body. As sympathetic arousal…
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  • 1. Beta-blockers
  • 2. Beta-blockers <ul><li>Beta-blockers, such as i , do not enter the brain, but directly r of the s around the body. As sympathetic arousal is a key feature of stressful states, beta-blockers can be very effective against symptoms such as r and . </li></ul>
  • 3. Beta-blockers <ul><li>Beta-blockers work by reducing the activity of and , which are key agents in sympathetic arousal. Adrenaline and noradrenalin are produced as part of the s response to stress, and circulate in the bloodstream, stimulating b receptors in various parts of the body, including the and . </li></ul>
  • 4. Beta-blockers <ul><li>Beta-blockers, such as inderal , do not enter the brain, but directly reduce activity in pathways of the sympathetic nervous system around the body. As sympathetic arousal is a key feature of stressful states, beta-blockers can be very effective against symptoms such as raised hear rate and blood pressure . </li></ul>
  • 5. Beta-blockers <ul><li>Beta-blockers work by reducing the activity of adrenaline and noradrenaline , which are key agents in sympathetic arousal. Adrenaline and noradrenalin are produced as part of the sympathomedullary response to stress, and circulate in the bloodstream, stimulating beta-adrenergic receptors in various parts of the body, including the heart, brain and blood vessels . </li></ul>
  • 6. Beta-blockers <ul><li>For example, stimulation of beta-adrenergic receptors on heart cells causes an increase in the force and rate of the heartbeat. The beta-blocker drug binds to beta-adrenergic receptors and blocks the receptor from being stimulated. By blocking sympathetic arousal, beta-blockers slow the heartbeat, lessens the force with which the heart contracts, and reduces blood vessel contraction. This results in a fall in blood pressure and therefore produces less stress on the heart. </li></ul>
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