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  REFERENCES Akiyama, T. and M. C. Savin (2010). Populations of antibiotic-resistant coliform bacteria change rapidly in a wastewater effluent dominated stream. Science of the Total Environment, Volume 408  (24), 6192-6201. Al-Rifai, J. H., et al, (2007). Occurrence of pharmaceutically active and non-steroidal estrogenic compounds in three different wastewater recycling schemes in Australia. Chemosphere , Volume 69 , 803-815. Arikan, O. A., et al  , (2006). The fate and effect of oxytetracycline during the anaerobic digestion of manure from therapeutically treated calves.  Process Biochemistry , Volume 41 , 1637-1643. Auerbach, E. A., E. E. Seyfried and K. D. McMahon (2007). Tetracycline resistance genes in activated sludge wastewater treatment plants. Water Research , Volume 41 (5), 1143-1151. Austin, S. T. (1998). Shreve’s Chemical Process Industries, 5 th  Edition, McGraw-Hill, U.S.A. Backhaus, T. and L. H. Grimme (1999). The toxicity of antibiotic agents to the luminescent  bacterium Vibrio fischeri. Chemosphere, Volume 38 (14), 3291-3301. Baguer, A. J., et al, (2000). Effects of the antibiotics oxytetracycline and tylosin on soil fauna. Chemosphere , Volume 40  (7), 751-757. Barrett, F. F., et al,  (1968). Methicillin-resistant Staphylococcus aureus  at Boston City Hospital. Bacteriologic and epidemiologic observations. The New England Journal of  Medicine, Volume 279 (9), 441-448. Beyer, A. and M. Matthies (2001). Criteria for atmospheric transport potential and  persistence of pesticides and industrial chemicals. Preliminary Final Report FKZ 299 65 402, German Federal Environmental Agency, Berlin, Germany. Bjorklund, H., et al  , (1991). Residues of oxolinic acid and oxytetracycline in fish and sediments from farms.  Aquaculture, Volume 97 , 85-96 Boxall A. B., et al, (2003). Are veterinary medicines causing environmental risks?.  Environmental Science and Technology,  Volume 37 (15), 286A-294A. Boxall, A. B., et al,  (2006). Uptake of veterinary medicines from soils into plants.  Journal of  Agricultural and Food Chemistry, Volume 54 (6), 2288-2297. Brown, K. D., et al  , (2006). Occurrence of antibiotics in hospital, residential, and dairy effluent, municipal wastewater, and the Rio Grande in New Mexico. Science of the Total  Environment, Volume 366 , 772-783. Cars, O. and P. Nordberg (2005). Antibiotic resistance  –   The faceless threat.  Internation  Journal of Risk and Safety in Medicine, Volume 17 , 103-110.  Choo, P. S. (1994). Degradation of oxytetracycline hydrochloride in fresh and seawater.  Asian Fisheries Science , Volume 7 , 195-200. Clive, D. L. J. (1968). Chemistry of tetracyclines. Quarterly Review of the Chemical Society, Volume 22 , 435-457. Cohen, M. L., et al,  (1982). 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Monitoring and evaluation of antibiotic-resistant bacteria at a municipal wastewater treatment plant in China.  Environment International  , Volume 42 , 31-36. Jacobsen, P. and L. Berglind (1988). Persistence of oxytetracycline in sediments from fish farms.  Aquaculture , Volume 70 (4), 365-370.  Katz, S. E. (1985). Environmental impact assessment for the use of oxytetracycline to treat/control respiratory and digestive tract infections in captively-reared alligators. Department of Biochemistry and Microbiology, Rutgers  –   The State University of New Jersey, New Jersey, pp. 15. Kim, S. C. and K. Carlson (2007). Quantification of human and veterinary antibiotics in water and sediment using SPE/LC/MS/MS.  Analytical and Bioanalytical Chemistry,   Volume 387  (4), 1301-1315. Klecka, G. M. (2000). Evaluation of Persistence and Long-Range Transport of Organic Chemicals in the Environment. Society of Environmental Toxicology and Chemistry, Pensacola, pp. 362. Kolpin, D. W., et al, (2002). Pharmaceuticals, hormones, and other organic wastewater contaminants in US streams, 1999-2000: A national reconnaissance.  Environmental Science and Technology, Volume 36 , 1202-1211. Kumar, A. and H. P. Schweizer (2005). Bacterial resistance to antibiotics: active efflux and reduced uptake.  Advanced Drug Delivery Reviews, Volume 57 (10), 1486-1513. Kumar, K., et al, (2005). Antibiotic Uptake by Plants from Soil Fertilized with Animal Manure.  Journal of Environmental Quality, Volume 34 (6), 2082-2085. Kummerer, K. (2004). Resistance in the environment.  Journal of Antimicrobial Chemotherapy, Volume 54 , 311-320. Kummerer, K. (2008). Pharmaceuticals in the Environment, 3 rd  Edition, Springer, U. S. A. Kummerer, K. (2009). Antibiotics in the aquatic environment  –   A review. Chemosphere, Volume 75 , 417-434. Lai, H. T., et al,  (1995). 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Determination and fate of oxytetracycline and related compounds in oxytetracycline production wastewater and the receiving river.  Environmental Toxicology and Chemistry , Volume 27 , 80-86. Loke, M. L., et al, (2002). Determination of the distribution coefficient (Log  K  d  ) of oxytetracycline, tylosin A, olaquindox, and metronidazole in manure. Chemosphere, Volume 48 , 351-361. Mackay, D. (2001). Multimedia Models: The Fugacity Approach, 2 nd  Edition, Lewis Publishers, Boca Raton, FL, U.S.A. Mackay, D., et al,  (1991). Assessment of chemical fate in Canada. Continued development of a fugacity model. Health Canada, Bureau of Chemical Hazards, Ottawa, ON. Mackay, D., et al, (1996). Evaluating the environmental fate of types of chemicals using the EQC model.  Environmental Toxicology and Chemistry, Volume 15 , 1627-1637. McKone, T. E. (1993). CalTox, a multimedia total-exposure model for hazardous waste sites  part II the dynamic multimedia transport and transformation model. Department of Toxic Substances Control  –   Lawrence Livermore National Laboratory, California. Miao, X. S., et al, (2004). Occurrence of antimicrobials in the final effluents of wastewater treatment plants in Canada.  Environmental Science and Technology, Volume 38  (13), 3533-3541. Miege, C., et al, (2009). Fate of pharmaceuticals and personal care products in wastewater treatment plants  –   conception of a database and first results.  Environmental Pollution, Volume 157 , 1721-1726.  Nikaido, H. (1996). Multidrug efflux pumps of gram-negative bacteria.  Journal of  Bacteriology, Volume 178 (20), 5853-5859.  Ntakirutimana, T. (2012). Pollution and potential ecological risk assessment of heavy metals in a lake.  Polish Journal of Environmental Studies,  Volume 22 (4), 1129-1134. Pouliquen, H., et al,  (1993). Experimental study on the decontamination kinetics of seawater  polluted by oxytetracycline contained in effluents released from a fish farm located in a salt marsh.  Aquaculture, Volume 112 , 113-123. Rubin, R. J., et al, (1999). The economic impact of Staphylococcus aureus infection in New York City hospitals.  Emerging Infectious Diseases, Volume 5  (1), 9-17. Samuelsen, O. B. (1989). Degradation of oxytetracycline in seawater at two different temperatures and light intensities, and the persistence of oxytetracycline in the sediment from a fish farm.  Aquaculture, Volume 83 , 7-16. Simon, N. S. (2005). Loosely bound oxytetracycline in riverine sediments from two tributaries of the Chesapeake Bay.  Environmental Science and Technology, Volume 39 , 3480-3487.
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