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Sarcoidosis

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  What Is Sarcoidosis?Sarcoidosis (sar-koy-DO-sis) is a disease of unknown cause that leads to inflammation. This disease affects your bodys or!ans. ormally# your immune system defends your body a!ainst forei!n or harmful substances. $or e%am&le# it sends s&ecial cells to &rotect or!ans that are in dan!er.These cells release chemicals that recruit other cells to isolate and destroy the harmful substance. Inflammation occurs durin! this &rocess. Once the harmful substance is !one# the cells and the inflammation !o away.In &eo&le who ha'e sarcoidosis# the inflammation doesnt !o away. Instead# some of the immune system cells cluster to form lum&s called !ranulomas (!ran-yu-O-mas) in 'arious or!ans in your body.Sarcoidosis can affect any or!an in your body. *owe'er# its more likely to affect some or!ans than others. The disease usually starts in the lun!s# skin# and+or lym&h nodes (es&ecially the lym&h nodes in your chest). ,lso# the disease often affects the eyes and li'er. ,lthou!h less common# sarcoidosis can affect the heart and brain# leadin! to serious com&lications.If many !ranulomas form in an or!an# they can affect how the or!an works. This can cause si!ns and sym&toms. Si!ns and sym&toms 'ary de&endin! on which or!ans are affected. any &eo&le who ha'e sarcoidosis ha'e no si!ns or sym&toms or mild ones.of!rens syndrome is a classic set of si!ns and sym&toms that is ty&ical in some &eo&le who ha'e sarcoidosis. of!rens syndrome may cause fe'er# enlar!ed lym&h nodes# arthritis (usually in the ankles)# and+or erythema nodosum (er-ih-T*-ma no-DO-sum).rythema nodosum is a rash of red or reddish-&ur&le bum&s on your ankles and shins. The rash may be warm and tender to the touch.Treatment for sarcoidosis 'aries de&endin! on which or!ans are affected. /our doctor may &rescribe to&ical treatments and+or medicines to treat the disease. ot e'eryone who has sarcoidosis needs treatment.OutlookThe outlook for sarcoidosis 'aries. any &eo&le reco'er from the disease with few or no lon!-term &roblems.ore than half of the &eo&le who ha'e sarcoidosis ha'e remission within 0 years of dia!nosis. 12emission3 means the disease isnt acti'e# but it can return.Two-thirds of &eo&le who ha'e the disease ha'e remission within 45 years of dia!nosis. 6eo&le who ha'e of!rens syndrome usually ha'e remission. 2ela&se (return of the disease) 4 or more years after remission occurs in less than 7 &ercent of &atients.Sarcoidosis leads to or!an dama!e in about one-third of the &eo&le dia!nosed with the disease. Dama!e may occur o'er many years and in'ol'e more than one or!an. 2arely# sarcoidosis can be fatal. Death usually is the result of &roblems with the lun!s# heart# or brain.  6oor outcomes are more likely in &eo&le who ha'e ad'anced disease and show little im&ro'ement from treatment.8ertain &eo&le are at hi!her risk for &oor outcomes from chronic (lon!-term) sarcoidosis. This includes &eo&le who ha'e lun! scarrin!# heart or brain com&lications# or lu&us &ernio (9-&us 692-ne-o). u&us &ernio is a serious skin condition that sarcoidosis may cause.2esearch is on!oin! for new and better treatments for sarcoidosis.What 8auses Sarcoidosis?The cause of sarcoidosis isnt known. ore than one factor may &lay a role in causin! the disease.Some researchers think that sarcoidosis de'elo&s if your immune system res&onds to a tri!!er# such as bacteria# 'iruses# dust# or chemicals. ormally# your immune system defends your body a!ainst forei!n or harmful substances. $or e%am&le# it sends s&ecial cells to &rotect or!ans that are in dan!er.These cells release chemicals that recruit other cells to isolate and destroy the harmful substance. Inflammation occurs durin! this &rocess. Once the harmful substance is !one# the cells and the inflammation !o away.In &eo&le who ha'e sarcoidosis# the inflammation doesnt !o away. Instead# some of the immune system cells cluster to form lum&s called !ranulomas in 'arious or!ans in your body.:enetics also may &lay a role in sarcoidosis. 2esearchers belie'e that sarcoidosis occurs if;/ou ha'e a certain !ene or !enes that raise your risk for the disease<,nd</oure e%&osed to somethin! that tri!!ers your immune systemTri!!ers may 'ary de&endin! on your !enetic makeu&. 8ertain !enes may influence which or!ans are affected and the se'erity of your sym&toms.2esearchers continue to try to &in&oint the !enes that are linked to sarcoidosis.Who Is at 2isk for Sarcoidosis?Sarcoidosis affects &eo&le of all a!es and races. *owe'er# its more common amon! ,frican  ,mericans and orthern uro&eans. In the 9nited States# the disease affects ,frican ,mericans somewhat more often and more se'erely than Whites.Studies ha'e shown that sarcoidosis tends to 'ary amon!st ethnic !rou&s. $or e%am&le# eye &roblems related to the disease are more common in =a&anese &eo&le.of!rens syndrome# a ty&e of sarcoidosis# is more common in &eo&le of uro&ean descent. of!rens syndrome may in'ol'e fe'er# enlar!ed lym&h nodes# arthritis (usually in the ankles)# and+or erythema nodosum. rythema nodosum is a rash of red or reddish-&ur&le bum&s on your ankles and shins. The rash may be warm and tender to the touch.Sarcoidosis is somewhat more common in women than in men. The disease usually de'elo&s between the a!es of >5 and 75. 6eo&le who ha'e a family history of sarcoidosis also are at hi!her risk for the disease.2esearchers ha'e looked for a link between sarcoidosis and e%&osure to work&lace and  en'ironmental factors. *owe'er# no clear link has been found.

156-164-1-PB

Jul 23, 2017
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