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  THERAPEUTIC DRUG MONITORING (TDM) Dr. Chaichan Sangdee   Department of Pharmacology   Faculty of Medicine   Chiang Mai University    DO ALL DRUGS NEED TDM?   Drugs that do not need TDM:   Drugs that used for treating diseases of which their clinical end points can easily be monitored, e.g., BP, HR, cardiac rhythm, blood sugar, blood cholesterol and triglycerides, urine volume, body temperature, inflammation, pain, headache, etc.  Drugs whose serum concentrations do not correlate with therapeutic or toxic effects.  Drugs with less complicated pharmacokinetics.  Drugs that used to treat less complicated or not life threatening diseases    COMMONLY MONITORED DRUGS   1 . Bronchodilators: Theophylline   2 . Antibiotics   : Aminoglycosides - Gentamicin, Amikacin   : Others - Vancomycin   3 . Immunosuppressants: Cyclosporine  4 . Anticancers: Methotrexate    COMMONLY MONITORED DRUGS (cont’d)   5 . Antiepileptics: Phenobarbital, Phenytoin,   Carbamazepine, Valproate 6. Cardiac Drugs : Digoxin*, Procainamide, Lidocaine 7. Psychoactive Drugs: Lithium, TCA   8. Analgesics: Aspirin, Paracetamol

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