Textbook of Neuro-Oncology

Textbook of Neuro-Oncology
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  The Curtis Center170 S Independence Mall W300EPhiladelphia, Pennsylvania 19106-3399TEXTBOOK OF NEURO-ONCOLOGYISBN: 0-7216-8148-4 Copyright ©2005 by ElsevierInc. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic ormechanical, including photocopy, recording, or any information storage and retrieval system, withoutpermission in writing from the publisher. Permissions may be sought directly from Elsevier Inc. RightsDepartment in Philadelphia, Pennsylvania, USA: telephone: ( + 1)215-238-7869, fax: ( + 1)215-238-2239, e-mail: You may also complete your request on-line via the Elsevierhomepage, by selecting “Customer Support” and then “Obtaining Permissions.”NOTICENeurosurgery is an ever-changing field. Standard safety precautions must be followed, but as new researchand clinical experience broaden our knowledge, changes in treatment and drug therapy may becomenecessary or appropriate. Readers are advised to check the most current product information provided bythe manufacturer of each drug to be administered to verify the recommended dose, the method andduration of administration, and contraindications. It is the responsibility of the treating physician, relyingon experience and knowledge of the patient, to determine dosages and the best treatment for eachindividual patient. Neither the Publisher nor the authors assume any liability for any injury and/or damage to persons or property arising from this publication.The Publisher Library of Congress Cataloging-in-Publication Data Textbook of neuro-oncology / [edited by] Mitchel S. Berger, Michael D. Prados. – 1st ed.p.;cm.Includes index.ISBN 0-7216-8148-41.Nervous system–Tumors.I.Berger, Mitchel S.II.Prados, Michael.[DNLM:1.Brain Neoplasms.2.Neoplasms, Neuroepithelial.3.Peripheral Nervous System Neoplasms.4.Skull Base Neoplasms. 5.Spinal Cord Neoplasms.WL358 T355 2005]RC280.N4T49 2005616.99 ¢ 481–dc222004042996  Acquisitions Editor  : Rebecca Schmidt Gaertner  Developmental Editor  : Denise LeMelledo Publishing Services Manager  : Joan Sinclair Project Manager  : Cecelia BayrunsPrinted in China.Last digit is the print number:987654321  P REFACE To this end, we enlisted the aid of some of the mostrespected people working in the field. Ossama Al-Mefty, at theUniversity of Arkansas, signed up to deal with tumors of thecranial base. Ray Sawaya, at the University of Texas M.D.Anderson Cancer Center, said he would take on the section onbrain metastasis. Paul McCormick of the Columbia Presbyter-ian Medical Center and the Neurological Institute of New York agreed to help out with a section on tumors of the spinal axistogether with Andy Parsa, who has since joined us in San Francisco. Michel Kliot, at the University of WashingtonSchool of Medicine in Seattle, agreed to edit the section onperipheral nerve tumors together with Keith Kwok. Jim Rutka,at the University of Toronto’s Hospital for Sick Children,agreed to edit the section on pediatric neuro-oncology, and ourcolleague Evren Keles joined forces in editing the section onthe treatment of intracranial tumors in adults. With this world-class team working with us, we felt we could produce a com-prehensive text that would be useful for everyone immersed inor interested by the field of neuro-oncology. These sectioneditors have done their part, enlisting a distinguished panel of specialists who have provided chapters that more than fulfillour optimistic hopes for this textbook. Together with our felloweditors, we hope you will find this volume both an interestingand useful resource.Mitchel S. Berger, MDMichael D. Prados, MD  Editors It takes an integrated multidisciplinary approach to provide thebest care for patients with brain tumors, and in consulting withour colleagues on the patient-care team we’ve often been frus-trated by the lack of an all-inclusive resource that provides acomprehensive picture of the multifaceted aspects of the chal-lenges involved. In working with our colleagues doing basicscience research into the causes and mechanisms of braintumors, we have been impressed by their interest in the clini-cal details of translational therapies developed through theircreative work. With the enthusiasm and support of the pub-lisher, we were encouraged to outline a book intended foreveryone curious to understand more about the varied clinicalroles in the treatment of brain tumors and the basic biology andepidemiology of this most perplexing disease.This book is intended for everyone on the medical teamcaring for patients with brain tumors, from the physicians whofirst suspect the diagnosis, to the neuroradiologists involved in diagnostic work-ups, to the medical specialists in neuro-oncology who monitor care, to radiation oncologists and neurosurgeons. It is a “Tumor Board in Print” where each spe-cific type of brain tumor occupies a chapter in which all of themultidisciplinary specialists involved in treating that specifictumor are heard. We have also tried to make this a book forother members of the patient-care team, for residents and students interested in brain tumors, and in particular for basicscientists wanting to understand more about the clinical com-plexities of managing neuro-oncology patients.  CONTRIBUTORS Joann Aaron, MA Scientific EditorDepartment of Neuro-OncologyUniversity of Texas M.D. Anderson Cancer CenterHouston, Texas24:  Mixed Gliomas Emad T. Aboud, MD Fellow, Department of NeurosurgeryUniversity of Arkansas for Medical SciencesLittle Rock, Arkansas52:  Epidermoid Tumors A. Leland Albright, MD Professor of NeurosurgeryUniversity of Pittsburgh School of Medicine;Chief of Pediatric NeurosurgeryChildren’s Hospital of PittsburghPittsburgh, Pennsylvania87:  Hypothalamic Hamartomas Kenneth D. Aldape, MD Associate Professor of PathologyUniversity of Texas M.D. Anderson Cancer CenterHouston, Texas24:  Mixed Gliomas 27:  Astroblastoma Mubarak Al-Gahtany, MD, FRCSC Clinical Fellow in NeurosurgeryThe University of TorontoToronto Western HospitalToronto, Ontario, Canada74:  Malignant Peripheral Nerve Tumors 107: Peripheral Nerve Tumors in Children Ossama Al-Mefty, MD Professor and Chair of NeurosurgeryUniversity of Arkansas for Medical SciencesLittle Rock, Arkansas44:  Nonacoustic Schwannomas of the Cranial Nerves 45:  Meningiomas 46:  Meningeal Hemangiopericytomas and Sarcomas 48: Chordomas and Chondrosarcomas of theCranial Base 49: Paragangliomas of the Skull Base Nabeel Al-Shafai, MD Neurosurgery ResidentThe University of TorontoToronto Western HospitalToronto, Ontario, Canada97: Choroid Plexus Tumors ChristopherAmes, MD Assistant Professor of Neurological SurgeryUniversity of California, San Francisco,School of MedicineSan Francisco, California69:  Benign Tumors of the Spine Lilyana Angelov, MD Associate Staff Department of Neurological SurgeryThe Cleveland ClinicCleveland, Ohio30:  Mixed Neuronal and Glial Tumors Edgardo J. Angtuaco, MD Professor, Department of RadiologyUniversity of Arkansas for Medical Sciences;Chief, Division of NeuroradiologyUniversity of Arkansas for Medical Sciences 45:  Meningiomas 48: Chordomas and Chondrosarcomas of theCranial Base Henry E. Aryan, MD Clinical Instructor of NeurosurgeryUniversity of California, San Diego, School of Medicine;NeurosurgeonUniversity of California, San Diego, Medical Center;Children’s Hospital Medical CenterSan Diego, California101: Pediatric Skull Base Tumors Kurtis Ian Auguste, MD Resident PhysicianDepartment of Neurological SurgeryUniversity of California San Francisco School of MedicineSan Francisco, California40:  Hemangioblastomas SamerAyoubi, MD, FRCS Attending PhysicianDamascus University School of Medicine;Consultant NeurosurgeonAl-Muwasat University HospitalDamascus, Syria44:  Nonacoustic Schwannomas of the Cranial Nerves 46:  Meningeal Hemangiopericytomas and Sarcomas Matthew T. Ballo, MD Associate Professor of Radiation OncologyUniversity of Texas M.D. Anderson Cancer CenterHouston, Texas61: Skull Base Metastasis Geoffrey R. Barger, MD Associate ProfessorDepartment of NeurologyWayne State University School of Medicine;Co-Chief, Neuro-OncologyKarmanos Cancer InstituteDetroit, Michigan35:  Medulloblastoma Fred G. BarkerII, MD Assistant Professor of NeurosurgeryHarvard Medical School;Assistant Visiting NeurosurgeonMassachusetts General HospitalBoston, Massachusetts20: Pilocytic Astrocytoma 34: Pineoblastoma Gene H. Barnett, MD, FACS Professor of SurgeryCleveland Clinic Lerner College of Medicine;ChairmanThe Brain InstituteCleveland, Ohio30:  Mixed Neuronal and Glial Tumors Michael E. Berens, PhD Senior InvestigatorTGen, The Translational Genomics ResearchInstitutePhoenix, Arizona3:  Animal Models Mitchel S. Berger, MD Professor and Chair of Neurological SurgeryKathleen M. Plant Distinguished Professor of Neurological SurgeryDirector, Brain Tumor Research CenterUniversity of California, San Francisco, School of MedicineSan Francisco, California1:  Epidemiology of Brain Tumors 9: Surgical Strategies in the Management of BrainTumors 17:  Diffuse Astrocytoma 28: Gliomatosis Cerebri 40:  Hemangioblastomas of the Central NervousSystem Mark Bernstein, MD, FRCSC Professor of SurgeryThe University of Toronto;NeurosurgeonToronto Western HospitalUniversity Health Network Toronto, Ontario, Canada22: Subependymal Giant Cell Astrocytoma and Tuberous Sclerosis Complex  Ratan D. Bhardwaj, MD Neurosurgical ResidentThe University of TorontoToronto, Ontario, Canada94: Pituitary Tumors in Children Asis KumarBhattacharyya, MBBS, MS, MCh Fellow, Division of NeurosurgeryUniversity of TorontoToronto Western HospitalToronto, Ontario, Canada22: Subependymal Giant Cell Astrocytoma and Tuberous Sclerosis Complex  Juan M. Bilbao, MD Associate Professor of PathologyThe University of Toronto;NeuropathologistSunnybrook HospitalToronto, Ontario, Canada80:  Lhermitte-Duclos Disease Mark H. Bilsky, MD Assistant Attending, Department of SurgeryMemorial Sloan-Kettering Cancer CenterCornell University Medical CenterNew York, New York 71: Therapeutic Options for Treating MetastaticSpine Tumors Devin K. Binder, MD, PhD Chief ResidentDepartment of Neurological SurgeryUniversity of California, San Franciso,School of MedicineSan Francisco, California14: Gene Therapy for Malignant Gliomas


Jul 23, 2017


Jul 23, 2017
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