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Co- and Post-translational Protein Modifications of Therapeutics & Biopharmaceuticals
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  Co- and Post-translational Protein Modifications of Therapeutics & Biopharmaceuticals By Dr. Mohamed Ramadan Hassan Attalla Director of Biotech. / Bio-similar Products & Recombinant DNA / Protein Vaccines R&D Center  –   R&D Sector VACSERA , Egypt   PTMs are covalent chemical modification either during their ribosomal translation or often after its synthesis is complete.  Key role in functional Proteomics.  Regulate activity, localization and interaction with other cellular molecules, e.g., proteins, nucleic acids, lipids and cofactors.   Introduction   Phosphorylation   Types of PTMs  Glycosylation  Methylation  Proteolysis  Ubiquitination   Amidation  N-Acetylation  S-Nitrosylation  Sulfation  Carboxylation  Lipidation  Prenylation
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