Sevoflurane Uso

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  SAFETY DATA SHEET 1. Identification Product identifier SevofluraneOther means of identificationCatalog number  1612540 Chemical name Propane, 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)- Recommended use Specified quality tests and assay use only. Recommended restrictions Not for use as a drug. Not for administration to humans or animals. Manufacturer/Importer/Supplier/Distributor informationTelephone RS Technical Services301-816-8129RockvilleMD20852-1790USU. S. Pharmacopeia Company nameAddressEmergency phone number  CHEMTREC within US &Canada1-800-424-9300CHEMTREC outside US &Canada+1 703-527-3887 WebsiteE-mail RSTECH@usp.orgwww.usp.org12601 Twinbrook Parkway 2. Hazard(s) identification Not classified. Physical hazards Category 2ASerious eye damage/eye irritation Health hazards Category 2Reproductive toxicityCategory 3 narcotic effectsSpecific target organ toxicity, singleexposureNot classified. OSHA hazard(s)Label elementsSignal word Warning Hazard statement Causes serious eye irritation. Suspected of damaging fertility or the unborn child. May causedrowsiness or dizziness. Precautionary statementPrevention Wash thoroughly after handling. Obtain special instructions before use. Do not handle until allsafety precautions have been read and understood. Wear protective gloves/protectiveclothing/eye protection/face protection. Avoid breathing mist or vapor. Use only outdoors or in awell-ventilated area. Response If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present andeasy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention. If exposed or concerned: Get medical advice/attention. If inhaled: Remove person to fresh air and keepcomfortable for breathing. Call a poison center/doctor if you feel unwell. Storage Store in a well-ventilated place. Keep container tightly closed. Store locked up. Disposal Dispose of contents/container in accordance with local/regional/national/international regulations.Not classified. Hazard(s) not otherwiseclassified (HNOC) 3. Composition/information on ingredients Substance 1 / 7 Material name: Sevoflurane7222 Version #: 04 Revision date: 08-07-2014 Issue date: 10-26-2010 USP SDS US  Hazardous componentsCAS number %Chemical nameCommon name and synonyms 28523-86-6Sevoflurane100 4. First-aid measures Inhalation If breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing.Call a physician if symptoms develop or persist. Skin contact Rinse skin with water/shower. Get medical attention if irritation develops and persists. Eye contact Rinse with water. Get medical attention if irritation develops and persists. Ingestion Rinse mouth. If ingestion of a large amount does occur, call a poison control center immediately. Most importantsymptoms/effects, acute anddelayed Irritation of eyes and mucous membranes. Narcotic effects. Indication of immediatemedical attention and specialtreatment needed Provide general supportive measures and treat symptomatically. Treatment of halogenatedhydrocarbon anesthetic overdose may include the following: Induced vomiting is NOTrecommended. Perform gastric lavage soon after ingestion (within 1 hour). Administer activatedcharcoal as a slurry. For circulatory depression or severe hypotension, infuse isotonic fluids andplace in Trendelenburg position. If hypotension persists, administer dopamine or norepinephrine.For bradycardia, administer atropine. For respiratory depression, establish a clear airway andadminister 100% oxygen. For malignant hyperthermia, administer 100% oxygen and dantrolenesodium, and reduce body temperature with external cooling methods, if needed. For metabolicacidosis, administer sodium bicarbonate. For hyperkalemia, administer oxygen, bicarbonate, andglucose and insulin. For bronchospasms and wheezing, administer a bronchodilator. For seizures,administer a benzodiazepine. If seizures persist, administer phenobarbital or propofol. (Mexitext)(Poisondex) General information Remove from exposure. Remove contaminated clothing. For treatment advice, seek guidancefrom an occupational health physician or other licensed health-care provider familiar withworkplace chemical exposures. In the United States, the national poison control center phonenumber is 1-800-222-1222. If person is not breathing, give artificial respiration. If breathing isdifficult, give oxygen if available. Persons developing serious hypersensitivity (anaphylactic)reactions must receive immediate medical attention. 5. Fire-fighting measures Suitable extinguishing media Water fog. Foam. Dry chemical powder. Carbon dioxide (CO2). Unsuitable extinguishingmedia Do not use water jet as an extinguisher, as this will spread the fire. Specific hazards arising fromthe chemical No unusual fire or explosion hazards noted. Special protective equipmentand precautions for firefighters Wear suitable protective equipment. Fire-fightingequipment/instructions Use water spray to cool unopened containers. As with all fires, evacuate personnel to a safe area.Firefighters should use self-contained breathing equipment and protective clothing. Specific methods Use standard firefighting procedures and consider the hazards of other involved materials. 6. Accidental release measures Personal precautions,protective equipment andemergency procedures Keep unnecessary personnel away. Do not touch damaged containers or spilled material unlesswearing appropriate protective clothing. Ensure adequate ventilation. Avoid inhalation of vapors.Wear appropriate personal protective equipment. Methods and materials for containment and cleaning up  Absorb spillage with suitable absorbent material. For waste disposal, see section 13 of the SDS.Clean surface thoroughly to remove residual contamination. 7. Handling and storage Precautions for safe handling  As a general rule, when handling USP Reference Standards, avoid all contact and inhalation of dust, mists, and/or vapors associated with the material. Clean equipment and work surfaces withsuitable detergent or solvent after use. After removing gloves, wash hands and other exposedskin thoroughly. Conditions for safe storage,including any incompatibilities Store in tight container as defined in the USP-NF. This material should be handled and stored per label instructions to ensure product integrity.2 / 7 Material name: Sevoflurane7222 Version #: 04 Revision date: 08-07-2014 Issue date: 10-26-2010 USP SDS US  8. Exposure controls/personal protection Exposure limit valuesIndustrial UseValueMaterialType TWA10 ppmSevofluran e (CAS28523-86-6) Biological limit values No biological exposure limits noted for the ingredient(s). Appropriate engineeringcontrols  Airborne exposure should be controlled primarily by engineering controls such as general dilutionventilation, local exhaust ventilation, or process enclosure. Local exhaust ventilation is generallypreferred to general exhaust because it can control the contaminant at its source, preventingdispersion into the work area. An industrial hygiene survey involving air monitoring may be usedto determine the effectiveness of engineering controls. Effectiveness of engineering controlsintended for use with highly potent materials should be assessed by use of nontoxic surrogatematerials. Individual protection measures, such as personal protective equipmentEye/face protection Safety glasses with sideshields are recommended. Face shields or goggles may be required if splash potential exists or if corrosive materials are present. Approved eye protection (e.g., bearingthe ANSI Z87 or CSA stamp) is preferred. Maintain eyewash facilities in the work area. Skin protectionHand protection Chemically compatible gloves. For handling solutions, ensure that the glove material is protectiveagainst the solvent being used. Use handling practices that minimize direct hand contact.Employees who are sensitive to natural rubber (latex) should use nitrile or other synthetic nonlatexgloves. Use of powdered latex gloves should be avoided due to the risk of latex allergy. Other  For handling of laboratory scale quantities, a cloth lab coat is recommended. Where significantquantities are handled, work clothing may be necessary to prevent take-home contamination. Respiratory protection Where respirators are deemed necessary to reduce or control occupational exposures, useNIOSH-approved respiratory protection and have an effective respirator program in place(applicable U.S. regulation OSHA 29 CFR 1910.134). Thermal hazards Not available. General hygieneconsiderations Handle in accordance with good industrial hygiene and safety practice. 9. Physical and chemical properties Appearance Clear, colorless, volatile liquid. Physical state Liquid. Form Liquid. Odor  Nonpungent odor. Odor threshold Not available. pH 7 - 7.5 Melting point/freezing point 32 - 77 °F (0 - 25 °C) Initial boiling point and boilingrange 136.4 - 137.48 °F (58 - 58.6 °C) Flash point Not available. Evaporation rate > 1 Flammability (solid, gas) Not applicable. Upper/lower flammability or explosive limitsFlammability limit - lower (%) Not available. Flammability limit - upper (%) Not available. Explosive limit - lower (%) Not available. Explosive limit - upper (%) Not available. Vapor pressure 25.73 kPa at 25 °C197 - 200 mm Hg Vapor density 6.94 (Air = 1) Relative density 1.1 Solubility in water  Slightly soluble. Partition coefficient(n-octanol/water) Not available.3 / 7 Material name: Sevoflurane7222 Version #: 04 Revision date: 08-07-2014 Issue date: 10-26-2010 USP SDS US  Auto-ignition temperature Not available. Decomposition temperature Not available. Viscosity Not available. Other informationChemical family Halogenated hydrocarbon (methyl ethyl ether).. Molecular formula C4H3F7O Molecular weight 200.05 Solubility (other) Soluble in ethanol, in chloroform, and in ether; miscible with petroleum benzene. Specific gravity 1.52 - 1.525 10. Stability and reactivity Reactivity No reactivity hazards known. Chemical stability Material is stable under normal conditions. Possibility of hazardousreactions No dangerous reaction known under conditions of normal use. Conditions to avoid None known. Incompatible materials  Alkaline metals. Strong bases. Hazardous decompositionproducts F-. Irritating and/or toxic fumes or gases. Emits toxic fumes under fire conditions. 11. Toxicological information Information on likely routes of exposureIngestion Based on available data, the classification criteria are not met. Inhalation Vapors have a narcotic effect and may cause headache, fatigue, dizziness and nausea. Skin contact Due to lack of data the classification is not possible. Eye contact Causes serious eye irritation. Symptoms related to thephysical, chemical, andtoxicological characteristics Halogenated hydrocarbon anesthetics: Dizziness. Headache. Slow heartbeat. Low bloodpressure. Lethargy. Blurred vision. Chest pain. Shortness of breath. Temporary absence or cessation of breathing. Nausea. Vomiting. Upset stomach. Loss of appetite. Cough. Sore throat.Excitement. Agitation. Salivation. Speech disturbances. Uncontrolled movements. Tremor.Seizures. Delayed and immediate effectsof exposure Halogenated hydrocarbon anesthetics: Muscle relaxation. Bronchospasm. Laryngospasm.Respiratory depression. Unconsciousness. Death. Cross sensitivity Persons sensitive to one halogenated hydrocarbon anesthetic may be sensitive to this materialalso. Medical conditions aggravatedby exposure Halogenated hydrocarbon anesthetics: History of or predisposition to malignant hyperthermia.Impaired liver or kidney function. Asthma. Coronary artery disease. Muscular dystrophy.Convulsive disorders. Myasthenia gravis. Head injury or increased intracranial pressure, tumors,or lesions. Acute toxicity Based on available data, the classification criteria are not met. Test ResultsProductSpecies Sevoflurane (CAS 28523-86-6)LC50Mouse Inhalation 28300 ppm, 3 hr Rat28800 ppm, 3 hr LD50Mouse Oral  18200 mg/kgRat10800 mg/kg Skin corrosion/irritation Due to lack of data the classification is not possible. Serious eye damage/eyeirritation Causes serious eye irritation. Local effects Irritancy test (animals)Result: Irritant.Organ: Eye.Severity: Mild to moderate. Respiratory sensitization Due to lack of data the classification is not possible. Skin sensitization Due to lack of data the classification is not possible.4 / 7 Material name: Sevoflurane7222 Version #: 04 Revision date: 08-07-2014 Issue date: 10-26-2010 USP SDS US
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