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12-Immunopathology_Part_2.pdf

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Part I - SLE Dr. Samir Ayad 1 Systemic Lupus Erythematosus (SLE) Definition: Autoimmune disease of connective tissue that involves multiple systems. Incidence: - 1:2500 - Sex: females to males (9:1) - Age: 20-40 years at onset (mostly) Dr. Samir Ayad 2 Etiology: (1) Genetic factors: - familial incidence - HLA-DR2 and DR3 (2) Immunological factors: - deficiency of suppresor T-cells - hyperactive helper T-cells - abnormal B-cells (3) Drugs - induced (e.g. hydralazine, procainamide) (4) Vi
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  Dr. Samir Ayad 1 Part I - SLE  Dr. Samir Ayad 2 Systemic Lupus Erythematosus(SLE) Definition: Autoimmune disease of connective tissue that involves multiple systems. Incidence: -1:2500-Sex: females to males (9:1)-Age: 20-40 years at onset (mostly)  Dr. Samir Ayad 3 Etiology: (1) Genetic factors:-familial incidence-HLA-DR2 and DR3(2) Immunological factors:-deficiency of suppresor T-cells -hyperactive helper T-cells-abnormal B-cells(3) Drugs-induced (e.g. hydralazine, procainamide)(4) Viral infection(5) Sex hormones(exacerbations in pregnancy)  Dr. Samir Ayad 4 Mechanism: (a) Autoimmune disease: antinuclear antibodies(ANAs) against several nuclear antigens (DNA,RNA, nucleoproteins)  react with nuclei of damaged cells (cannot penetrate intact cells)(b) Formation of immune complexesand their deposition in different tissues(c) Activation of complement  inflammatory lesions( type III hypersensitivity   )
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