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N-Methyl-D-Aspartic Acid (NMDA) powder (6384-92-5) for Bodybuilding Overview

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https://www.wisepowder.com/product-details/6384-92-5/N-methyl-d-aspartic acid powder is well-known in sports nutrition industry among bodybuilders and fitness lovers for its testosterone-boosting benefits. N-methyl-d-aspartic acid powder, abbreviated
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  www.wisepowder.com wise12@wisepowder.com1  /  4 N-Methyl-D-Aspartic Acid (NMDA)powder (6384-92-5) for Bodybuilding Overview N-Methyl-D-aspartic acid powder or N-Methyl-D-aspartate (NMDA) is an amino acidderivative that acts as a specific agonist at the NMDA receptor mimicking the actionof glutamate, the neurotransmitter which normally acts at that receptor. Unlikeglutamate, NMDA only binds to and regulates the NMDA receptor and has no effecton other glutamate receptors (such as those for AMPA and kainate). NMDAreceptors are particularly important when they become overactive duringwithdrawal from alcohol as this causes symptoms such as agitation and, sometimes,epileptiformseizures.  www.wisepowder.com wise12@wisepowder.com2  /  4 NMDA(6384-92-5) videoNMDA(6384-92-5) Base Information Name N-Methyl-D-Aspartic Acid (NMDA) powderCAS 6384-92-5Purity 98%Chemical name N-Methyl-D-aspartic acidSynonyms LC488A; LC 488A; LC-488AMolecular Formula C5H9NO4Molecular Weight 147.13 g/molMelting Point 189 to 190 ° CInChI Key HOKKHZGPKSLGJE-GSVOUGTGSA-NForm SolidAppearance White powderHalf Life UnknownSolubility Soluble in DMSOStorage Condition Dry, dark and at 0- 4 C for short term (days to weeks) or -20C for long term (months to years).ApplicationN-methyl-D-aspartic acid is an aspartic acid derivativehaving an N-methyl substituent and D-configuration. It hasa role as a neurotransmitter agent. It is a D-alpha-aminoacid, a D-aspartic acid derivative, an amino dicarboxylic acidand a secondary amino compound.Testing Document Available NMDA (6384-92-5) General Description N-Methyl-D-aspartic acid (NMDA) powder is an endogenously generated molecule inrat nervous system and endocrine glands. NMDA is present at low level (nmol/g) inthe adenohypophysis, hypothalamus, brain, and testis. NMDA is derived from D-Aspby an S-adenosylmethionine-dependent enzyme also referred to as NMDA synthase. NMDA (6384-92-5) powder History N-Methyl-D-aspartic acid powder is an amino acid derivative acting as a specificagonist at the NMDA receptor, and therefore mimics the action of the  www.wisepowder.com wise12@wisepowder.com3  /  4 neurotransmitter glutamate on that receptor. In contrast to glutamate, NMDA bindsto and regulates the above receptor only, but not other glutamate receptors. NMDAis a water-soluble synthetic substance that is not normally found in biological tissue.It was first synthesized in the 1960’s.NMDA is an excitotoxin; this trait has applications in behavioral neuroscienceresearch. The body of work utilizing this technique falls under the term “lesionstudies.” Researchers apply NMDA to specific regions of an (animal) subject’s brainor spinal cord and subsequently test for the behavior of interest, such as operantbehavior.If the behavior is compromised, it suggests the destroyed tissue was part of a brainregion that made an important contribution to the normal expression of thatbehavior. Examples of antagonists of the NMDA receptor are APV,dextromethorphan, ketamine, phencyclidine (PCP), riluzole, and memantine. Theyare commonly referred to as NMDA receptor antagonists. NMDA (6384-92-5) Mechanism Of Action How does n-methyl-d-aspartic acid work? There is no much scientific information onthis area, but we are to explain the acts in a simple way.N-methyl-D-aspartic acid (NMDA) acts as a specific agonist at the NMDA receptor,and therefore mimics the action of the neurotransmitter glutamate on that receptor.As we know, glutamate is the excitatory neurotransmitter found in most synapses of the central nervous system, and pharmacologists made this analogue to activate asub-type of glutamate receptors. Since there are multiple glutamate receptors, youcan distinguish between them pharmacologically with different drugs, and NMDA isone of those drugs. In contrast to glutamate, NMDA binds to and regulates theNMDA receptor only, with no effect on other glutamate receptors.D-Aspartic Acid breaks down into N-Methyl-D-Aspartic acid via a methyl transferencereaction called NMDA Synthetase. N-Methyl-D-Aspartate then stimulates theHypothalamus-Pituitary and testes to produce hormones. Therefore, if you takeD-Aspartic Acid, it is the N-Methyl-D-Aspartic Acid, which gets there throughconversion that actually does the work by increasing testosterone levels as well asgrowth hormone and luteinizing hormone. NMDA (6384-92-5) Application What is n-methyl-d-aspartic acid? N-methyl-d-aspartic acid is well-known in sportsnutrition industry among bodybuilders and fitness lovers for its  www.wisepowder.com wise12@wisepowder.com4  /  4 testosterone-boosting benefits. N-methyl-d-aspartic acid, abbreviated as NMDA, hasseveral other names such as N-Methyl-D-aspartate, N-Methyl aspartic acid,(R)-2-(Methylamino) succinic acid, etc. NMDA (6384-92-5) More research When we talk about N-methyl-d-aspartic acid, you can never forget D-Aspartic acid(DAA). DAA is an excitatory amino acid while N-methyl-d-aspartic acid (NMDA) isdeemed to be 100 times more potent than D-aspartic acid at stimulating the NMDAreceptor. patrick Arnold is believe to be an active chemist inventor with DAA andNMDA. NMDA (6384-92-5) Document Download COA NMDA (6384-92-5) Reference 1, “N-Methylaspartate – Compound Summary”. PubChem Compound. USA: NationalCenter for Biotechnology Information. 24 June 2005. Identification. Retrieved 9January 2012.2, Dingledine, R; Borges K (Mar 1999). “The glutamate receptor ion channels”.Pharmacol. Rev. 51 (1): 7–61. PMID 10049997.3, Liu, Y; Zhang J (Oct 2000). “Recent development in NMDA receptors”. Chin Med J(Engl). 113 (10): 948–56. PMID 11775847.4, Cull-Candy, S; Brickley S (Jun 2001). “NMDA receptor subunits: diversity,development and disease”. Current Opinion in Neurobiology. 11 (3): 327–35.doi:10.1016/S0959-4388(00)00215-4. PMID 11399431.
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