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Cellular Mechanisms in the Induction and Regulation of Experimental Allergic Encephalomyelitis

Experimental Allergic Encephalomyelitis (EAE) is an autoimmune demyelinating disease of the central nervous system (CNS) with pathological and clinical features, including patterns of remission and relapse, reminiscent the human disease Multiple
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  NationalLibrary of CanadaBibliothèquenationaleduCanadaAcquisitionsandDirection des acquisitions et BibliographieServicesBranchdesservicesbibliographiques 395Wellington Street 395. rue Wellington Ottawa,OntarioOttawa(Ontario) K1AON4 K1AON4 NOTICEAVISThequality of thismicroform isheavilydependentuponthequality of theoriginalthesissubmitted for microfilming.Everyefforthasbeenmade to ensurethehigl:'lestquality of reproductionpossible. If pagesaremissing,contacttheuniversitywhichgrantedthedegree.Sornepages may have indistinctprint especially if theoriginalpagesweretypedwithapoortypewriterribbonor if theuniversitysent us aninferiorphotocopy.Laqualitédecettemicroformedépendgrandementdelaqualitédelathèsesoumiseaumicrofilmage.Nousavons tout fait pour assurer une qualitésupérieuredereproduction.S'ilmanquedes pages,veuillez .communiqueravecl'université qui aconférélegrade.LaqUétlitéd'impressiondecertainespages peut laisser à désirer, surtout silespagessrcinales ont étédactylographiées à l'aide d'un rubanuséousil'université nous afaitparvenirunephotocopiede.qualitéinférieure.Reproductioninfull or in part of thismicroform is governed by u theCanadian Copyright Act,R.S.C.1970, c. C-30,andsubsequentamendments. o (j Lareproduction,mêmepartielle,decettemicroformeesj:soumise " " \ . ~ à laLoicanadienne sur le droit d'auteur,SRC1970,c.C-30,etsesamendementssubséquents. •ù Canada  • CELLULARMECHANISMS IN THEINDUCTIONANDREGULATIONOFEXPERIMENTALALLERGICENCEPHALOMYELITIS by RanaZeine,M.D. - A" ThesissubmittedtotheFaculty of GraduateStudiesandResearch ln partialfulfillment of therequirementsforthedegree of Doctor of Philosophy © Rana2eine,1993 " ' , ~ Department of Medicine Division of ExperimentalMedicineMcGillUniversity"Montreal,Quebec 1 ',;  1+1 NationalLibraryofCanadaBibliothèquenationaleduCanadaAcquisitions and Directiondesacquisitions et BibliographieServicesBranchdesservicesbibliographiques 395Wellington Street395. rue WellingtonOttawa,OntarioOttawa(Ontario) K1A ON4 K1A ON4 Theauthorhasgrantedanirrevocablenon-exclusivelicenceallowingtheNationalLibrary of Canada,,!. to reproduce;loan,distribute.orsellcopies ofhis/her thesisby any means andinanyform or format,makingthisthesis available(o interestedpersons.Tgeauthorretains o w n e r ~ h i p of jhe copyright in his/her thesis. ; ~ 7 Neitherthethesis nor substantialextractsfrom it maybeprinted or otherwisereproduced without . his/her permission.L'auteuraaccordéunelicenceirrévocableetnonexclusivepermettant à laBibliothèquenationale du Canadadereproduire,prêter,distribuerouvendredescopiesdesathèse .' dequelquerri'ânièreetsousquelqueformequece soitpour mettredesexemplairesdecette .. thèse à ladispositiondespersonnesintéressées;L'auteurconservelapropriétédu droit d'auteur qui protègesathèse.Nilathèsenidesextraitssubstantielsdecelle-cinedoiventêtreimprimésouautrementreproduitssanssonautorisation. ISBN 0-315-87875-4 Canada  (: THESIS SUBMISSIONName:,ZEINE 1 RANA Degree:Ph.D. Shortened version ofthe thesis title: "INDUCTION AND REGULATION OF EXPERIMENTALALLERGIC ENCEPHALOMYELITIS ,--- :::,  • Thisthesisisdedicated tG ailthepeoplewhoarepatientl)' .... uffering from MultipleSclerosis r ~ 2
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