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Final Exam 2013 Sample Epidemiology of Infectious Diseases

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Final written exam for Epidemiology of Infectious Diseases
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  Final exam  –  Epidemiology of Infectious Diseases 2013 Page 1 of 7 Name: Don’t forget to put your name above!   THERE ARE 16 QUESTIONS (plus one bonus) IN TOTAL   This is a take home exam. You may use the textbook, your notes from class, and other materials available on Blackboard or online to find the answers to the questions. You may not consult with others (in the class or othewise) about your answers. The exam is to be completed electronically and submitted by June   13, 2013 at 11:59 pm  through the Assignment submission link for the final exam in Blackboard  .DO NOT EMAIL EXAMS TO THE INSTRUCTOR . The exam is designed so that the text for questions is protected. The area for answers (in blue) is flexible in size, but most questions require only brief answers. Some questions are multiple choice. For these you can just enter the letter of the answer(s) you chose. Below is a list of diseases that have been covered in lectures and in student presentations in class. These are the only diseases about which you’ll need to know specific things to answer the questions.   Anthrax Kuru Bacterial meningitis Lyme disease Bovine spongiform encephalopathy Pertussis Clostridium difficile Plague Chagas disease Poliomyelitis Chickenpox Rubella Cytomegalovirus Salmonellosis Ebola Shingles Gonorrhea Syphilis Hepatitis A Toxoplasmosis Hepatitis B Trachoma Hepatitis C Tuberculosis HIV/AIDS variant CJD (vCJD) Invasive Group A Streptococcus Check your answers for accuracy and completeness before submitting. There will be a substantial penalty for late submissions.  Final exam  –  Epidemiology of Infectious Diseases 2013 Page 2 of 7 1. Name five diseases from the list where the known or putative causal agent is not a virus or bacterium, and name the causal agent for each:  Answer here: Disease Agent 1. 2 3 4 5 2. Which of the following is usually the primary motivation for epidemiologists conducting an outbreak investigation: (Choose one.) a. to control the spread the disease b. to treat those infected with the disease c. to educate the public about disease risk d. to develop a cure for the disease  Answer :  Final exam  –  Epidemiology of Infectious Diseases 2013 Page 3 of 7 3.  A disease “outbreak” is loosely defined as a sudden increase in disease incidence, above what is expected in a specific population. There are some diseases where the ocurrence of even a single case is considered an outbreak requiring immediate investigation. From the following list, choose one  that you think should require immediate investigation if only a single human case were seen in Philadelphia and briefly explain why . (There is more than one possible correct answer. Your explanation of the reasons is key.) Possible diseases: Cutaneous anthrax Cytomegalovirus Lyme disease Salmonellosis Chickenpox in a pregnant woman Gonorrhea Clostridium difficile Syphilis Plague Toxoplasmosis Poliomyelitis Hepatitis C Rubella in a pregnant woman HIV/AIDS Skin infection with invasive Group A Streptococcus Write name of disease and explanation here: 4. As of April 2013, what countries  were considered by the WHO Global Polio Eradication Initiative to have endemic wild type 1 poliovirus?  Answer here: 5. There are two major behavioral risk factors for prevalent HIV/AIDS in US women. Which one was the most common before 1994? After 1994?  Answers here: Before 1994:  After 1994:  Final exam  –  Epidemiology of Infectious Diseases 2013 Page 4 of 7 6. Why did AIDS activists push for adoption of prognostic markers to predict outcomes in clinical trials of anti-retroviral medicines? (State briefly in 2-3 sentences.)  Answer here: 7. Which type of vaccine (live attenuated or inactivated) most has the characteristic listed in the lefthand column of the table below? (Mark X in the column for the vaccine time that is superior.) Enter answers in table: Live attenuated Inactivated Immune response includes cell-mediated immunity Less sensitive to storage conditions Requires more doses to attain immunity Requires replication in vaccinee to be effective May be unsafe to use in immunocompromised persons 8. Name two viral infections from the list that can cause serious illness and birth defects in infants born to infected mothers:  Answer here:
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